MAGNesium and Digoxin Versus AMiodarone for Fast Atrial Fibrillation in the ICU (MAGNAM Trial)

Status: Recruiting
Location: See all (5) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

A multi-centre, non-blinded, comparative effectiveness, randomised controlled trial. Patients will be prospectively enrolled from Critical Care Units and will be assessed for study enrollment based on inclusion/exclusion criteria at the time of the onset of fast atrial fibrillation (AF)(irregular and often rapid heart rate). The authors hypothesize that high dose Magnesium Sulphate with the addition of Digoxin as a second line treatment will improve the success rate in returning the heart to normal rhythm as well as speed of resolution of critical illness in new onset rapid atrial fibrillation in the critically ill cared for in general ICUs.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Admitted to a participating hospital ICU

• A newly documented episode of fast Atrial Fibrillation with heart rate \>120/min confirmed by a 12-lead ECG assessment regardless of baseline rhythm (note- The AF can be acute or chronic diagnosis)

• Undergoing, or able to commence continuous electrocardiographic monitoring (telemetry) as part of their routine clinical care

• Treating physician determines the patient has clinically significant AF that requires medical treatment

Locations
Other Locations
Canada
Mount Sinai Hospital
RECRUITING
Toronto
St Michael's Hospital
RECRUITING
Toronto
Sunnybrook Health Sciences Centre
RECRUITING
Toronto
University Health Network - Toronto General Hospital
RECRUITING
Toronto
University Health Network - Toronto Western Hospital
RECRUITING
Toronto
Contact Information
Primary
Brian H Cuthbertson, MD
brian.cuthbertson@sunnybrook.ca
416 480 6100
Backup
Project Manager
MAGNAM@sunnybrook.ca
Time Frame
Start Date: 2022-01-05
Estimated Completion Date: 2026-04-30
Participants
Target number of participants: 200
Treatments
Experimental: Experimental arm
Intravenous magnesium sulphate as first line followed by digoxin IV loading as second line and then amiodarone IV as third line treatments for fast Atrial Fibrillation
Active_comparator: Standard of care arm
Intravenous amiodarone as compactor group intervention
Related Therapeutic Areas
Sponsors
Leads: Sunnybrook Health Sciences Centre
Collaborators: Sunnybrook Research Institute

This content was sourced from clinicaltrials.gov