Characterization of Arrhythmia Substrate to Ablate Persistent Atrial Fibrillation (Coast-AF) Randomized Clinical Trial
Status: Recruiting
Location: See all (15) locations...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
A multicentre, parallel group, two arm, single-blinded randomized clinical trial, assessing the efficacy of a patient-tailored catheter ablation (CA) strategy guided by atrial scar mapping in addition to pulmonary vein isolation (PVI) when compared to PVI alone in patients with persistent atrial fibrillation (AF).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Age ≥18 years ;
• Subjects with symptomatic persistent AF AND clinically indicated catheter ablation for AF
• At least one episode of AF that is sustained beyond 3 months in duration ; documented on 12-lead ECG, Holter monitor, loop monitor or trans-telephonic monitor (TTM) within 36 months of enrollment in the study;
• Modified DR-FLASH score \>=4
⁃ 4\. Subjects must be able to provide informed consent.
Locations
Other Locations
Canada
Libin Cardiovascular Institute
RECRUITING
Calgary
QEII Health Sciences Centre, Nova Scotia Health Authority
RECRUITING
Halifax
Hamilton General Hospital
RECRUITING
Hamilton
London Health Sciences Centre
NOT_YET_RECRUITING
London
Centre Hospitalier de l'Universite de Montreal (CHUM)
RECRUITING
Montreal
McGill University Health Centre
RECRUITING
Montreal
Montreal Heart Institute
RECRUITING
Montreal
Sacre-Coeur Hospital
RECRUITING
Montreal
Southlake Regional Health Centre
RECRUITING
Newmarket
University of Ottawa Heart Institute
RECRUITING
Ottawa
Institute Universitaire de Cardiologie et Pneumologie du Quebec (IUCPQ)
RECRUITING
Québec
CIUSSS de L'Estrie-CHUS-Hopital Fleurimont
RECRUITING
Sherbrooke
Rouge Valley Regional Heart Centre
RECRUITING
Toronto
St. Michael's Hospital
NOT_YET_RECRUITING
Toronto
Vancouver General Hospital
RECRUITING
Vancouver
Contact Information
Primary
Pablo Nery, MD
pnery@ottawaheart.ca
613-696-7272
Backup
Tammy Knight
tknight@ottawaheart.ca
613-696-7000
Time Frame
Start Date: 2018-08-24
Estimated Completion Date: 2024-12
Participants
Target number of participants: 502
Treatments
Active_comparator: Pulmonary Vein Isolation
Wide area circumferential catheter ablation for pulmonary vein isolation
Experimental: Pulmonary Vein Isolation and scar ablation
Wide area circumferential catheter ablation for pulmonary vein isolation and scar ablation
Authors
Related Therapeutic Areas
Sponsors
Leads: Ottawa Heart Institute Research Corporation
Collaborators: Heart and Stroke Foundation of Canada