Chloroquine for Patients With Symptomatic Persistent Atrial Fibrillation: A Prospective Pilot Study

Who is this study for? Patients with Atrial Fibrillation
What treatments are being studied? Chloroquine Phosphate
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

The goal of this pilot study is to explore the efficacy of chloroquine in terminating persistent AF and assess its potential role as a pharmacological cardioversion agent for the management of AF.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age 18 years and older

• History of symptomatic persistent AF Persistent AF - defined as continuous AF that is sustained more than 7 days but less than 12 months. Episodes of AF of ≥ 48 hours duration in which a decision is made to terminate with electrical or pharmacological cardioversion prior to 7 days will also be classified as persistent AF

• AF must be documented at least once either by ECG, event monitoring, loop recorder, telemetry, trans-telephonic monitoring, pacemaker or cardiac defibrillator readouts within 24 months prior to enrollment

• Currently on anticoagulation therapy as indicated per local guidelines, which is considered optimal for stroke prevention in the opinion of the investigator

• Implanted dual chamber pacemaker/ICD capable of monitoring atrial arrhythmias or willingness to wear a 2 weeks event monitor if patient does not have a device capable of monitoring atrial arrhythmias

• Signed informed consent

Locations
United States
Florida
University of South Florida
RECRUITING
Tampa
Contact Information
Primary
Thanh Tran, MPH
thanhtran@health.usf.edu
813-844-8544
Backup
Sami Noujaim, PhD
snoujaim@health.usf.edu
813-974-6416
Time Frame
Start Date: 2017-03-28
Estimated Completion Date: 2020-09
Participants
Target number of participants: 40
Treatments
Experimental: Chloroquine Phosphate
Chloroquine Phosphate will be provided at 500 mg dosage strength for oral administration. Patient will be instructed to take 2 tablets per day on the first two days and 1 tablet each day for the next 12 days for a total of 14 days treatment.
Related Therapeutic Areas
Sponsors
Leads: University of South Florida

This content was sourced from clinicaltrials.gov