A Prospective Study Using Intra-Pericardial Amiodarone for the Prevention of Postoperative Atrial Fibrillation (POAF) in Patients Undergoing Cardiac Arterial Bypass Grafting and/or Valve Surgery

Status: Recruiting
Location: See location...
Intervention Type: Combination product
Study Type: Interventional
Study Phase: Early Phase 1
SUMMARY

The purpose of this study is to evaluate the combination of CardiaMend, with the addition of amiodarone in the prevention of postoperative atrial fibrillation (POAF) in patients undergoing cardiac arterial bypass grafting (CABG) or valve surgery.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 20
Maximum Age: 85
Healthy Volunteers: f
View:

• Subject aged 20-85 years old.

• Patients able to provide written informed consent, understand, and be willing to comply with study-related procedures.

• Participants who are scheduled to undergo open-chest cardiac surgery via complete median sternotomy. Includes:

‣ Coronary artery bypass graft (CABG) and/or valve repair/replacement procedures (aortic, mitral, or tricuspid)

⁃ Isolated ascending aortic aneurysm replacement/repair

⁃ Note: Left atrial appendage (LAA) procedures are allowed if CABG and/or valve repair or replacement is the qualifying surgical procedure, but is not a qualifying surgical procedure on its own.

• In sinus rhythm at the time of office visit and prior electrocardiogram (EKG) (note: continuous EKG monitoring for 48 hours is not required).

Locations
United States
Illinois
The University of Chicago
RECRUITING
Chicago
Contact Information
Primary
Valluvan Jeevanandam, MD
jeevan@bsd.uchicago.edu
773-702-2500
Backup
Leila Yazdanbakhsh, MSCI
leila.yazdanbakhsh@bsd.uchicago.edu
773-834-5087
Time Frame
Start Date: 2024-02-15
Estimated Completion Date: 2027-06
Participants
Target number of participants: 63
Treatments
Experimental: CardiaMend Pericardial and Epicardial Reconstruction Matrix used in combination with amiodarone
Patients randomized to this study arm includes the CardiaMend which will be used according to the instructions for use. It will be patted dry to facilitate implantation. Pieces will be cut to cover the right and left atria. The remaining piece will be contoured to close the anterior pericardial space. Four ampules of amiodarone (150mg/3ml; 12cc total volume) will be drawn into a syringe. 2cc will be dripped over the right atrium and a small CardiaMend patch placed to cover this area. Another 2cc will be used over the left atrium and covered with the CardiaMend. The anterior pericardial space will be closed without putting pressure on the underlying structures using the CardiaMend attached to the native pericardium utilizing running 4-0 monofilament suture.
No_intervention: University of Chicago's standard of care in patients undergoing isolated CABG or valve surgery
The standard of care for this study at The University of Chicago is to ligate the left atrial appendage (LAA) during the proposed cardiac surgery (intra-operative) to reduce the occurrence of post operative atrial fibrillation (A-FIB) in combination with amiodarone injections (if applicable).
Related Therapeutic Areas
Sponsors
Collaborators: Helios Cardio Inc.
Leads: University of Chicago

This content was sourced from clinicaltrials.gov