Characterization of Left Atrial Substrate in Patients With Ventricular Arrhythmias

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

The goal of this observational study is to analyze the characteristics of left atrial electroanatomical maps in patients without a history of atrial fibrillation but with a high clinical risk of developing it, as indicated by the presence of structural heart disease or a CHA2DS2-VASc score ≥ 2 points. The study cohort will be compared to a historical cohort of patients with diagnosed atrial fibrillation in a propensity-matched fashion. The main questions it aims to answer are: * Are the left atrial electroanatomical changes a consequence or a precursor to the development of atrial fibrillation? * Are the left atrial electroanatomical findings different between patients with atrial fibrillation and those at high risk of developing it? * What is the prognostic impact of left atrial pathologic changes in patients without diagnosed atrial fibrillation in terms of cardiovascular outcomes?

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Absence of a prior history of atrial fibrillation or flutter.

• Patients presenting for ablation of any ventricular tachycardia related to structural heart disease or any ventricular arrhythmia with a CHA2DS2-VASc score ≥ 2.

Locations
Other Locations
Belgium
Universitair Ziekenhuis Brussel
RECRUITING
Jette
Contact Information
Primary
Andrea Sarkozy, MD, PhD
Andrea.Sarkozy@uzbrussel.be
0032 02476 3657
Time Frame
Start Date: 2023-11-08
Estimated Completion Date: 2027-10-31
Participants
Target number of participants: 50
Treatments
Left atrial mapping group in patients without atrial fibrillation
Inclusion criteria:~* Age ≥ 18 years old.~* Absence of a prior history of atrial fibrillation or flutter.~* Patients presenting for ablation of any ventricular tachycardia related to structural heart disease or any ventricular arrhythmia with a CHA2DS2-VASc score ≥ 2.~Exclusion criteria:~* Presence of thrombus in the left atrial appendage.~* Complications related to the index procedure.~* Insufficient quality of the left atrial electroanatomical map.
Related Therapeutic Areas
Sponsors
Leads: Universitair Ziekenhuis Brussel

This content was sourced from clinicaltrials.gov