RECURrence of Atrial Fibrillation After Cardioversion of Patients Randomized to Open-label Treatment With Dapagliflozin or Usual Care

Status: Recruiting
Location: See all (7) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

The goal of this clinical trial is to learn if drug dapagliflozin, a sodium-glucose transport-2 inhibitor, works to treat atrial fibrillation in adults. The main question it aims to answer is: • Does the drug dapagliflozin reduce the recurrence rate of atrial fibrillation? Researchers will compare drug dapagliflozin to standard therapy to see if drug dapagliflozin reduce the recurrence of atrial fibrillation. Persons with atrial fibrillation who are planned for an electric cardioversion will: * Take the drug dapagliflozin, or no drug, once a day for a maximum of 56 days * Undergo a planned electric cardioversion of the atrial fibrillation * Record the rhythm with a hand-held device that transmits the signal to researchers during the study period, but no longer than for 56 days

Eligibility
Participation Requirements
Sex: All
Minimum Age: 55
Healthy Volunteers: f
View:

• Patients with AF on ECG who are planned for electrical cardioversion within 7-26 days from inclusion-date.

• Age ≥ 55 years.

• Provided written informed consent.

Locations
Other Locations
Sweden
Linköping university hosptial
NOT_YET_RECRUITING
Linköping
Örebro University hospital
RECRUITING
Örebro
Danderyds Hospital
NOT_YET_RECRUITING
Stockholm
Karolinska University Hospital
RECRUITING
Stockholm
Södersjukhuset
NOT_YET_RECRUITING
Stockholm
Norrlands universitetssjukhus
NOT_YET_RECRUITING
Umeå
Akademiska sjukhuset
NOT_YET_RECRUITING
Uppsala
Contact Information
Primary
Karolina Szummer, MD PhD
karolina.szummer@regionstockholm.se
+4681238000
Time Frame
Start Date: 2025-06-03
Estimated Completion Date: 2027-12
Participants
Target number of participants: 1600
Treatments
No_intervention: Usual care
Standard of care
Experimental: Dapagliflozin
Tablet Dapagliflozin 10 mg once daily
Related Therapeutic Areas
Sponsors
Collaborators: Karolinska Institutet
Leads: Region Stockholm

This content was sourced from clinicaltrials.gov