Attention Deficit Hyperactivity Disorder (ADHD) Clinical Trials

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Combining L-theanine and Paraxanthine for Transient Improvement of Cognitive Deficits Among Patients With Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder: A Series of Translational Pilot Neuroimaging Studies

Status: Recruiting

Location: See location...

Intervention Type: Dietary supplement

Study Type: Interventional

Study Phase: Not Applicable

SUMMARY

This pilot study will test whether combining L-theanine and paraxanthine improves sustained attention, inhibitory control, and overall cognition in adults with ADHD and ASD. Two parallel randomized, single-blinded, repeated-measures crossover trials will be conducted. Participants will complete neuropsychological testing, fMRI scanning, and self-report measures following administration of the L-theanine-paraxanthine combination compared to placebo.

Eligibility

Participation Requirements

Sex: Male

Healthy Volunteers: f

View:

• Adults (18+ years) diagnosed by a physician (per self-report) with ADHD or ASD

• \* Participants with a dual diagnosis and ASD and ADHD will be recruited but will only be included in the ASD group - their concurrent ADHD diagnosis will be included as an additional variable in exploratory analyses

Locations

United States

Texas

Texas Tech University

RECRUITING

Lubbock

Contact Information

Primary

Chathurika S Dhanasekara, MD, PhD

samudani.dhanasekara@ttuhsc.edu

806-743-2378

Backup

Chanaka N Kahathuduwa, MD, PhD

chanaka.kahathuduwa@ttuhsc.edu

806-412-9974

Time Frame

Start Date: 2025-10-01

Estimated Completion Date: 2026-06-01

Participants

Target number of participants: 24

Treatments

Experimental: Attention deficit hyperactivity disorder (ADHD)

A group of 12 adult males with Attention Deficit Hyperactivity Disorder (ADHD) will be enrolled. Each participant will receive both study conditions in a randomized, single-blinded, repeated-measures crossover design:~Active Condition: One capsule containing 200 mg L-theanine + 200 mg paraxanthine.~Placebo Condition: One capsule containing 400 mg of corn starch. The order of administration will be randomized, with each participant completing both conditions on separate visits (visits 2 and 3).

Experimental: Autism spectrum disorder (ASD)

A group of 12 adult males with autism spectrum disorder (ASD) will be enrolled. Each participant will receive both study conditions in a randomized, single-blinded, repeated-measures crossover design:~Active Condition: One capsule containing 200 mg L-theanine + 200 mg paraxanthine.~Placebo Condition: One capsule containing 400 mg of corn starch. The order of administration will be randomized, with each participant completing both conditions on separate visits (visits 2 and 3).

Related Therapeutic Areas

Autism Spectrum Disorder

Attention Deficit Hyperactivity Disorder (ADHD)

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