Predicting & Optimizing Language Outcomes in Minimally Verbal Children With Autism Spectrum Disorder: Boosting Language Outcomes of Minimally Verbal Children With ASD

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

In this project, the investigator will test the effect of augmenting an evidence based joint attention intervention (JASPER) with a motor-sound system intervention (PROMPT) compared to JASPER only on speech and language outcomes. The investigator will model change over a year to determine the percentage of children who cross the hurdle from single words to word combinations by Kindergarten. The proposed research will foster the understanding of the mechanisms underlying speech heterogeneity in ASD, thereby ultimately contributing to the development of more personalized, efficacious interventions. Upon qualification to the study (after entry assessments), the child will be randomized to receive JASPER alone (play-based intervention) or JASPER plus PROMPT (both play-based and speech-based interventions). The active intervention will last for 12 weeks, 60 minute sessions twice a week. There are assessments scheduled at entry (6.5 hours), end of study (exit-2.5 hours), 3 month follow up (2 hours), and when the child turns 6 years of age (2 hours). The total time commitment per participant is 37 hours.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 3
Maximum Age: 5
Healthy Volunteers: f
View:

• Children meeting ADOS-2 and ADI-R criteria for ASD

• age 42-66 months

• have had \> 3 months of early intervention/preschool (to ensure that children already have been exposed to some community interventions)

• walked prior to 24 months

• use \< 20 functional words (i.e., non-echoed, non-scripted). Number of functional spoken words will be totaled in a language sample assessment. The functional word criterion is based on a 2010 NIH workgroup definition of 'minimally verbal' in school-aged children. The same definition may also apply to younger children with limited language.

• stable medication over the past 6 months

• nonverbal mental age of \>12 months on the Mullen Scales of Early Learning (visual reception and fine motor subscales).

Locations
United States
California
UCLA
RECRUITING
Los Angeles
UCLA Semel Institute
RECRUITING
Los Angeles
Contact Information
Primary
Connie Kasari, PhD
kasari@gseis.ucla.edu
310-825-0575
Backup
Consuelo Garcia, BS
cogarcia@mednet.ucla.edu
310-825-4775
Time Frame
Start Date: 2021-04-29
Estimated Completion Date: 2026-08-31
Participants
Target number of participants: 50
Treatments
Experimental: JASPER only
This group will consist of the child and therapist having one-on-one, JASPER sessions, twice a week.
Active_comparator: JASPER + PROMPT
This group will consist of the child and therapist having one-on-one, JASPER sessions plus Prompts for Restructuring Oral Muscular Phonetic Targets (PROMPT), twice a week.
Related Therapeutic Areas
Sponsors
Leads: University of California, Los Angeles
Collaborators: National Institutes of Health (NIH)

This content was sourced from clinicaltrials.gov

Similar Clinical Trials