The Frequency of Osteosarcopenia and Its Relationship With Demographic and Clinical Factors in Axial Spondyloarthritis

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

Axial spondyloarthritis is a chronic inflammatory disease affecting the spine, sacroiliac joints, entheses, and sometimes peripheral joints with a close link to HLAB27. Typical features include inflammatory back pain, limited spinal mobility, and sacroiliitis. The term axial spondyloarthritis (AxSpA) includes both Ankylosing Spondylitis (AS) where sacroiliitis is diagnosed by X-rays, and non-radiographic AxSpA, where sacroiliitis is diagnosed via magnetic resonance imaging (MRI). Osteoporosis is common in AS patients, and sarcopenia may also develop due to inflammation and immobilization. Osteosarcopenia, the co-occurrence of osteoporosis and sarcopenia, might have an impact on morbidity and mortality of AxSpA patients. This cross-sectional study aims to determine the frequency of osteosarcopenia in AxSpA patients and to investigate its relationship with various demographic and clinical factors. A control group with similar age and gender distribution will be recruited to evaluate osteosarcopenia. Our hypothesis is that osteosarcopenia will be more frequent in the AxSpA group compared to the control group. The study will also identify the demographic and clinical factors associated with osteosarcopenia in AxSpa.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: t
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⁃ Patient group:

• Participants with a diagnosis of AxSpA: Participants with diagnosis of Ankylosing Spondylitis according to the modified New York criteria and participants with diagnosis of non-radiographic Spondyloarthritis (SpA) according to the Assessment of SpondyloArthritis International Society (ASAS) 2009 criteria.

• Aged 18-65 years

• Who gave consent to participate in the study

⁃ Healthy control group:

• Age- and gender-matched healthy participants (age 18-65)

• Who gave consent to participate in the study

Locations
Other Locations
Turkey
Ankara University Hospitals, Department of Physical Medicine and Rehabilitation
RECRUITING
Ankara
Contact Information
Primary
Ayşe A Küçükdeveci, MD
ayse.kucukdeveci@gmail.com
+90 312 5082850
Backup
İsmail Aksu, MD
draksuismail@gmail.com
+90 312 5082822
Time Frame
Start Date: 2023-09-01
Estimated Completion Date: 2025-04
Participants
Target number of participants: 97
Treatments
Axial Spondyloarthritis (AxSpA)
Participants with Axial Spondyloarthritis (AxSpA)
Sponsors
Leads: Ankara University

This content was sourced from clinicaltrials.gov