Correlation of RAFTLIN-1 Levels and Clinical Parameters in Axial Spondyloarthritis and Psoriatic Arthritis

Status: Completed
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Unlike other rheumatic diseases, acute phase reactants such as C-reactive protein and erythrocyte sedimentation rate are not diagnostic for patients with Spondyloarthropathies (SpA). Also, it is not possible to monitor disease activity with these tests. On the other hand, HLA-B27 positivity varies between races, and 8% of the normal population is HLA-B27 positive. In this manner, new biomarkers for endorsing the diagnosis and monitoring the disease activity are necessary. Acute phase reactants are not sensitive for diagnosing and assessing disease activity. This may lead to a diagnostic delay of up to 9 years. The investigators hypothesize that Raftlin-1, thought to have a regulatory role in TH17 function and IL-17-mediated immunity, may be a novel biomarker for showing inflammation-related clinical features.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: t
View:

• Being aged 18 to 65

• Meeting ASAS axial spondyloarthritis classification criteria

• Meeting The CASPAR (ClASsification criteria for Psoriatic ARthritis) criteria

Locations
Other Locations
Turkey
Bezmialem University
Istanbul
Time Frame
Start Date: 2023-03-21
Completion Date: 2023-07-09
Participants
Target number of participants: 119
Treatments
Active_comparator: Psoriatic arthritis
Patients meeting the CASPAR (ClASsification criteria for Psoriatic ARthritis) criteria
Active_comparator: Axial spondyloarthritis
Patients meeting the ASAS classification criteria for axial spondyloarthritis
Placebo_comparator: Healthy controls
Healthy people who do not have inflammatory conditions.
Sponsors
Leads: Bezmialem Vakif University

This content was sourced from clinicaltrials.gov