Learn About Psoriatic Arthritis
View Main Condition: Arthritis
Psoriatic arthritis is a joint problem (arthritis) that often occurs with a skin condition called psoriasis.
Arthritis - psoriatic; Psoriasis - psoriatic arthritis; Spondyloarthritis - psoriatic arthritis; PsA
Psoriasis is a common skin problem that causes red patches on the skin. It is an ongoing (chronic) inflammatory condition. Psoriatic arthritis occurs in 7% to 42% of people with psoriasis. Nail psoriasis is linked to psoriatic arthritis.
In most cases, psoriasis comes before the arthritis. In a few people, the arthritis comes before the skin disease. However, having severe, wide-spread psoriasis appears to increase the chance of getting psoriatic arthritis.
The cause of psoriatic arthritis is not known. Genes, immune system, and environmental factors may play a role. It is likely that the skin and joint diseases have similar causes. However, they may not occur together.
The arthritis may be mild and involve only a few joints. The joints at the end of the fingers or toes may be more affected. Psoriatic arthritis can cause arthritis only on one side of the body or both sides of the body.
In some people, the disease may be severe and affect many joints, including the spine. Symptoms in the spine include stiffness and pain. They most often occur in the lower spine and sacrum.
Some people with psoriatic arthritis may have inflammation of the eyes.
Most of the time, people with psoriatic arthritis have the skin and nail changes of psoriasis. Often, the skin gets worse at the same time as the arthritis.
Tendons may become inflamed with psoriatic arthritis. Examples include the Achilles tendon, the plantar fascia, and the tendon sheath in the hand.
Your provider may suggest nonsteroidal anti-inflammatory drugs (NSAIDs) to reduce pain and swelling of the joints.
Arthritis that does not improve with NSAIDs may need to be treated with medicines called disease-modifying antirheumatic drugs (DMARDs). These include:
- Methotrexate
- Leflunomide
- Sulfasalazine
Apremilast is another medicine used for the treatment of psoriatic arthritis.
Multiple injectable biologic medicines are effective for progressive psoriatic arthritis that is not controlled with DMARDs. These medicines block proteins involved in the inflammation process. They are often helpful for both the skin disease and the joint disease of psoriatic arthritis.
Additionally, there are two JAK-inhibitors that are approved for psoriatic arthritis: Tofacitinib and Upadacitinib. These medications are given orally.
Very painful joints may be treated with steroid injections. These are used when only one or a few joints are involved. Most experts do not recommend oral corticosteroids for psoriatic arthritis. Their use may worsen psoriasis and interfere with the effect of other medicines.
In rare cases, surgery may be needed to repair or replace damaged joints.
People with inflammation of the eye should see an ophthalmologist.
Your provider may suggest a mix of rest and exercise. Physical therapy may help increase joint movement. You may also use heat and cold therapy.
Dafna Gladman practices in Toronto, Canada. Ms. Gladman is rated as an Elite expert by MediFind in the treatment of Psoriatic Arthritis. Her top areas of expertise are Psoriatic Arthritis, Psoriasis, Arthritis, Systemic Lupus Erythematosus (SLE), and Kidney Transplant.
Regents Of The University Of California
Arthur Kavanaugh is a Rheumatologist and an Allergy and Immunologist in San Diego, California. Dr. Kavanaugh is rated as an Elite provider by MediFind in the treatment of Psoriatic Arthritis. His top areas of expertise are Psoriatic Arthritis, Arthritis, Psoriasis, and Rheumatoid Arthritis (RA).
Lihi Eder practices in Toronto, Canada. Ms. Eder is rated as an Elite expert by MediFind in the treatment of Psoriatic Arthritis. Her top areas of expertise are Psoriatic Arthritis, Psoriasis, Arthritis, and Synovitis.
The disease is sometimes mild and affects only a few joints. However, in many people with psoriatic arthritis damage to joints occurs within the first several years. In some people, very bad arthritis may cause deformities in the hands, feet, and spine.
Most people with psoriatic arthritis who do not improve with NSAIDs should see a rheumatologist, a specialist in arthritis, along with a dermatologist for the psoriasis.
Early treatment can ease pain and prevent joint damage, even in very bad cases.
Contact your provider if you develop symptoms of arthritis along with psoriasis.
Summary: Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects the joints and skin in people who have psoriasis (PsO). The main aim of the study is to know how well zasocitinib (TAK-279) works in participants with active PsA who have not previously been treated with biologic disease-modifying antirheumatic drugs. The participants will be treated with either zasocitinib, active comparator...
Summary: Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects the joints and skin in people who have psoriasis (PsO). The main aim of the study is to know how well zasocitinib (TAK-279) works in participants with active PsA based on their previous experience with specific treatments. The participants will be treated with either zasocitinib, or placebo. Participants will be in the study ...
Published Date: January 28, 2025
Published By: Diane M. Horowitz, MD, Rheumatology and Internal Medicine, Northwell Health, Great Neck, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Gossec L, Kerschbaumer A, Ferreira RJO, et al. EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2023 update Ann Rheum Dis 2024;83:706-719. PMID: 38499325 pubmed.ncbi.nlm.nih.gov/38499325/.
Haberman RH, Scher JU. Psoriatic arthritis. In: Firestein GS, McInnes IB, Koretzky GA, Mikuls TR, Neogi T, O’Dell JR, eds. Firestein & Kelley's Textbook of Rheumatology. 12th ed. Philadelphia, PA: Elsevier; 2025:chap 78.
Inman RD, Rahman P. Spondyloarthritis. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 244.
Veale DJ, Orr C. Management of psoriatic arthritis. In: Hochberg MC, Gravallese EM, Smolen JS, van der Hejjde D, Weinblatt ME, Weisman MH, eds. Rheumatology. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 131.