B-Cell Lymphoma Clinical Trials

∙ REGISTRATION ELIGIBILITY CRITERIA (STEP 1)

• Newly diagnosed patients with CD-22 positive B-cell acute lymphoblastic leukemia (WHO criteria) are eligible. Patients with Burkitt type ALL are NOT eligible

• Patients who have BCR-ABL fusion transcript determined by fluorescence in situ hybridization (FISH) or real time-polymerase chain reaction (RT-PCR) or t(9;22)(q34;q11) by cytogenetics are not eligible and should be considered for enrollment on studies that incorporate imatinib during induction; please note: flow cytometry is to be performed at the local reference lab and must include assessment of CD20 and CD22 positivity, as well as CD29 and CD22 anti-positivity

• No prior therapy except for limited treatment (\< 7 days) with corticosteroids or hydroxyurea and a single dose of intrathecal cytarabine

• No prior therapy for acute leukemia except emergency therapy (corticosteroids or hydroxyurea) for blast cell crisis, superior vena cava syndrome, or renal failure due to leukemic infiltration of the kidneys; when indicated, leukapheresis or exchange transfusion is recommended to reduce the WBC

• Single-dose intrathecal cytarabine is allowed prior to registration or prior to initiation of systematic therapy for patient convenience; systemic chemotherapy must begin within 72 hours of this intrathecal therapy

• Patients receiving prior steroid therapy are eligible for study; the dose and duration of previous steroid therapy should be carefully documented on case report forms

• Not pregnant and not nursing; for women of childbearing potential only, a negative urine or serum pregnancy test done =\< 7 days prior to registration is required

• Eastern Cooperative Oncology Group (ECOG) performance status 0-2

• Patients with down syndrome are excluded from this study

• Aspartate aminotransferase (AST), alanine aminotransferase (ALT) =\< 3 x upper limit of normal (ULN), unless suspected leukemic involvement of the liver

• Direct bilirubin =\< 3 x upper limit of normal (ULN), unless suspected leukemic involvement of the liver

• Calculated (calc.) creatinine clearance \>= 50 mL/min by Cockcroft-Gault

∙ RANDOMIZATION ELIGIBILITY CRITERIA (STEP 2)

• Completion of remission induction therapy

• Patients with M2 marrow or better are eligible; patients with M3 or M4 marrow (greater than 25% lymphoblasts) will not be eligible to be randomized

‣ Rating: M0, M1; Blast Cells (%): 0-5.0

⁃ Rating: M2; Blast Cells (%): 5.1-25.0

⁃ The term blast cell includes any cell that cannot be classified as a more mature normal element, and includes leukemic cells, pathologic lymphocytes, and stem cells

• No ascites, effusions or significant edema

• Absolute neutrophil count (ANC) \>= 1,000/mm\^3

• Platelet count \>= 100,000/mm\^3

• Total bilirubin =\< 1.5 x upper limit of normal (ULN), except for patients with known Gilbert's syndrome

• Aspartate aminotransferase (AST) =\< 8 x upper limit of normal (ULN)

• Completion of first 12 weeks (12+ weeks) of maintenance therapy (Course V)

• Patient has at least 24 weeks (24+ weeks) remaining before end of maintenance therapy (Course V)

• Patient is in complete continuous first remission at entry into A041501-HO1

• Patient is receiving oral anti-metabolite chemotherapy during the maintenance phase of therapy; treatment plan must call for the following doses of antimetabolites: 6MP 75 mg/m2/day orally; methotrexate (MTX) 20 mg/m2/week orally (modification of 6 MP or MTX dosing based on laboratory or clinical parameters is acceptable)

• Patient is able and willing to use the Medication Event Monitoring System (MEMS) TrackCap (e.g. not using a pillbox)