Brain Networks in Dystonia
Status: Recruiting
Location: See location...
Intervention Type: Procedure, Other
Study Type: Observational
SUMMARY
To date, there is only limited knowledge about the distinct neural abnormalities that lead to the development of different forms of focal dystonia. The goal of this study is to dissect the pathophysiological mechanisms underlying this clinical phenomenon using multi-level brain network analysis in patients with focal dystonia.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 21
Maximum Age: 80
Healthy Volunteers: t
View:
• Patients will have clinically documented focal dystonia
• Unaffected relatives of patients with focal dystonia
• Healthy controls will be healthy volunteers with a negative history of neurological, laryngeal or psychiatric problems
• Age from 21 to 80 years.
• Native English speakers.
• Right-handedness (based on Edinburgh Handedness Inventory).
Locations
United States
Massachusetts
Massachusetts Eye and Ear
RECRUITING
Boston
Contact Information
Primary
Kristina Simonyan, MD, PhD
Simonyan_Lab@MEEI.HARVARD.EDU
617-573-6016
Time Frame
Start Date: 2015-08-01
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 141
Treatments
Patients with dystonia and their unaffected relatives
Patients with dystonia and their unaffected blood relatives will undergo MRI of the brain and blood draw.
Healthy volunteers
Healthy subjects without any neurological, psychiatric or otolaryngological problems will undergo MRI of the brain and blood draw.
Related Therapeutic Areas
Sponsors
Leads: Massachusetts Eye and Ear Infirmary
Collaborators: National Institute of Dental and Craniofacial Research (NIDCR)