Longitudinal Cohort Study of Patients With Birdshot Chorioretinopathy.

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

The purpose of this study is twofold: 1. To analyze the clinical features of a cohort of patients with birdshot chorioretinopathy (BCR), an inflammatory bilateral ocular disease, affecting the choroid and the retina. Various imaging techniques will be used to assess the effect of the disease on the retina and the choroid. A standardized assessment of the visual function will be performed with visual acuity, visual field and color vision testing. The quality of life of the patients will be evaluated with the VFQ-25 questionnaire. These analyses will help delineating different forms of the disease among its heterogeneous presentations. 2. To identify predisposing factors for the disease. The condition is unique from the immunogenetic standpoint by its association with the HLA-A29 allele, which is the strongest link between an HLA class I antigen and a disease. To date, however, the mechanisms leading to birdshot chorioretinopathy remain unknown. GWAS (Genome Wide association Study) based on DNA of the cohort patients will be performed with the aim to identify other susceptibility genes associated with BCR.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Bilateral disease

• Presence of at least three peripapillary birdshot lesions inferior or nasal to the optic disk in one eye

• Low-grade anterior segment intraocular inflammation (defined as ≤ 1+cells in the anterior chamber)

• Low grade vitreous inflammatory reaction (defined as ≤ 2+ vitreous haze‡) Supportive findings

⁃ 1\. HLA-A29 positivity 2. Retinal vasculitis 3. Cystoid macular edema

Locations
Other Locations
France
Ophtalmopôle, Hôpital Cochin
RECRUITING
Paris
Contact Information
Primary
Souhila KECILI, MSc
souhila.kecili@aphp.fr
+33 1 58412898
Backup
Guillaume MASSON
guillaume.masson@aphp.fr
+33 1 58413478
Time Frame
Start Date: 2004-11-02
Estimated Completion Date: 2030-12-31
Participants
Target number of participants: 600
Treatments
Birdshot chorioretinopathy
Patients with a diagnosis of birdshot chorioretinopathy, with confirmed HLA-A29 positivity.
Related Therapeutic Areas
Sponsors
Leads: Assistance Publique - Hôpitaux de Paris

This content was sourced from clinicaltrials.gov

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