What is the definition of Botulism?

Botulism is a rare but serious illness caused by Clostridium botulinum bacteria. The bacteria may enter the body through wounds, or by eating them from improperly canned or preserved food.

What are the alternative names for Botulism?

Infant botulism

What are the causes for Botulism?

Clostridium botulinum is found in soil and untreated water throughout the world. It produces spores that survive in improperly preserved or canned food, where they produce a toxin. When eaten, even tiny amounts of this toxin can lead to severe poisoning. Foods that can be contaminated are home-canned vegetables, cured pork and ham, smoked or raw fish, and honey or corn syrup, baked potatoes cooked in foil, carrot juice, and chopped garlic in oil.

Infant botulism occurs when a baby eats spores and the bacteria grow in the baby's gastrointestinal tract. The most common cause of infant botulism is eating honey or corn syrup or using pacifiers that have been coated with contaminated honey.

Clostridium botulinum can be found normally in the stool of some infants. Infants develop botulism when the bacteria grow in their gut.

Botulism may also occur if the bacteria enter open wounds and produce toxins there.

About 110 cases of botulism occur in the United States each year. Most of the cases are in infants.

What are the symptoms for Botulism?

Symptoms often appear 8 to 36 hours after you eat food contaminated with the toxin. There is NO fever with this infection.

In adults, symptoms may include:

  • Abdominal cramps
  • Breathing difficulty that may lead to respiratory failure
  • Difficulty swallowing and speaking
  • Double vision
  • Nausea
  • Vomiting
  • Weakness with paralysis (equal on both sides of the body)

Symptoms in infants may include:

  • Constipation
  • Drooling
  • Poor feeding and weak sucking
  • Respiratory distress
  • Weak cry
  • Weakness, loss of muscle tone

What are the current treatments for Botulism?

You will need medicine to fight the toxin produced by the bacteria. The medicine is called botulinus antitoxin.

You will have to stay in the hospital if you have breathing trouble. A tube may be inserted through the nose or mouth into the windpipe to provide an airway for oxygen. You may need a breathing machine.

People who have trouble swallowing may be given fluids through a vein (by IV). A feeding tube may be inserted.

Providers must tell state health authorities or the US Centers for Disease Control and Prevention about people with botulism, so that the contaminated food is removed from stores.

Some people are given antibiotics, but they may not always help.

What is the outlook (prognosis) for Botulism?

Prompt treatment significantly reduces the risk for death.

What are the possible complications for Botulism?

Health problems that may result from botulism include:

  • Aspiration pneumonia and infection
  • Long-lasting weakness
  • Nervous system problems for up to 1 year
  • Respiratory distress

When should I contact a medical professional for Botulism?

Go to the emergency room or call the local emergency number (such as 911) if you suspect botulism.

How do I prevent Botulism?

NEVER give honey or corn syrup to infants younger than 1 year old -- not even just a little taste on a pacifier.

Prevent infant botulism by breastfeeding only, if possible.

Always throw away bulging cans or foul-smelling preserved foods. Sterilizing home-canned foods by pressure cooking them at 250°F (121°C) for 30 minutes may reduce the risk for botulism. Visit the Centers for Disease Control and Prevention website for more information on home canning safety at www.cdc.gov/foodsafety/communication/home-canning-and-botulism.html.

Keep foil-wrapped baked potatoes hot or in the refrigerator, not at room temperature. Oils with garlic or other herbs should also be refrigerated as should carrot juice. Make sure to set the refrigerator temperature at 50°F (10°C) or lower.

Bacteria

REFERENCES

Birch TB, Bleck TP. Botulism (Clostridium botulinum). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 245.

Norton LE, Schleiss MR. Botulism (Clostridium botulinum). In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 237.

  • Condition: Botulism
  • Journal: JCI insight
  • Treatment Used: 3,4-DAP
  • Number of Patients: 0
  • Published —
The study researched the safety and effectiveness of 3,4-DAP for treating symptoms of botulism.
  • Condition: Male Patients with Idiopathic Overactive Bladder Syndrome
  • Journal: The Journal of urology
  • Treatment Used: Intradetrusor OnabotulinumtoxinA Injection
  • Number of Patients: 146
  • Published —
This study assessed the treatment response, complications and treatment continuation after onabotulinumtoxinA injection in male patients.
Clinical Trial
  • Status: Active, not recruiting
  • Phase: Phase 1
  • Intervention Type: Drug
  • Participants: 30
  • Start Date: June 1, 2020
A Phase 1, Randomized, Double-Blind, Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of a Single IM Dose of G03-52-01 vs Placebo in Adult Subjects
Clinical Trial
  • Status: Recruiting
  • Phase: Phase 2
  • Intervention Type: Drug, Device
  • Participants: 20
  • Start Date: January 9, 2020
Effects of EMG-driven Robot-assisted Therapy for the Distal Upper Limb Motor Function in the Chronic Stroke Patients With Botox Injections