Learn About Botulism

What is the definition of Botulism?

Botulism is a rare but serious illness caused by Clostridium botulinum bacteria. The bacteria may enter the body through wounds or by eating improperly canned or preserved food.

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What are the alternative names for Botulism?

Infant botulism

What are the causes of Botulism?

Clostridium botulinum are found in soil and untreated water throughout the world. The bacteria produce protective spores to help them survive. In certain conditions, such as improperly preserved or canned food, these spores can grow and produce a toxin. When eaten, even tiny amounts of this toxin can lead to severe poisoning.

Foods that can be contaminated include:

  • Home-canned vegetables
  • Cured pork and ham
  • Smoked or raw fish
  • Honey or corn syrup
  • Baked potatoes cooked in foil
  • Carrot juice
  • Chopped garlic in oil

Infant botulism occurs when a baby eats Clostridium botulinum spores and the bacteria grow in the baby's intestines. The most common cause of infant botulism is eating honey or corn syrup or using pacifiers that have been coated with honey.

Clostridium botulinum can be found normally in the stool of some infants. Infants develop botulism when the bacteria grow in their gut.

Botulism may also occur if the bacteria enter open wounds and produce toxins there.

About 110 cases of botulism are reported in the United States each year. Most of the cases are in infants.

What are the symptoms of Botulism?

Symptoms often appear 8 to 36 hours after you eat food contaminated with the toxin. There is no fever with this infection.

In adults, symptoms may include:

  • Abdominal cramps
  • Breathing difficulty that may lead to respiratory failure
  • Difficulty swallowing and speaking
  • Double vision
  • Nausea
  • Vomiting
  • Weakness with paralysis (equal on both sides of the body)

Symptoms in infants may include:

  • Constipation
  • Drooling
  • Poor feeding and weak sucking
  • Respiratory distress
  • Weak cry
  • Weakness, loss of muscle tone
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What are the current treatments for Botulism?

You will need medicine to fight the toxin produced by the bacteria. The medicine is called botulism antitoxin.

You will have to stay in the hospital if you have breathing trouble. A tube may be inserted through the nose or mouth into the windpipe to provide an airway for oxygen. You may need a breathing machine.

People who have trouble swallowing may be given fluids through a vein (by IV). A feeding tube may be inserted.

Providers must tell state health authorities or the Centers for Disease Control and Prevention about people with botulism, so that the contaminated food is removed from stores.

Some people are given antibiotics, but they may not always help.

Who are the top Botulism Local Doctors?
Highly rated in

Istituto Superiore Di Sanità

Rome, IT 00161

Fabrizio Anniballi is in Rome, Italy. Anniballi is rated as an Elite expert by MediFind in the treatment of Botulism. He is also highly rated in 3 other conditions, according to our data. His top areas of expertise are Infant Botulism, Botulism, Food Poisoning, and Miller-Fisher Syndrome.

Highly rated in

Institut Pasteur

Paris, FR 

Christelle Mazuet is in Paris, France. Mazuet is rated as an Elite expert by MediFind in the treatment of Botulism. She is also highly rated in 3 other conditions, according to our data. Her top areas of expertise are Infant Botulism, Botulism, Food Poisoning, and Tetanus.

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Highly rated in


Université Paris Est 
Maisons-les-soulaines, FR 

Cedric Woudstra is in Maisons-les-soulaines, France. Woudstra is rated as an Elite expert by MediFind in the treatment of Botulism. He is also highly rated in 2 other conditions, according to our data. His top areas of expertise are Botulism, Infant Botulism, Tetanus, and Cat Scratch Disease.

What is the outlook (prognosis) for Botulism?

Prompt treatment greatly reduces the risk for death.

What are the possible complications of Botulism?

Health problems that may result from botulism include:

  • Aspiration pneumonia and infection
  • Long-lasting weakness
  • Nervous system problems for up to 1 year
  • Respiratory distress
When should I contact a medical professional for Botulism?

Go to the emergency room or call the local emergency number (such as 911) if you suspect botulism.

How do I prevent Botulism?

NEVER give honey or corn syrup to infants younger than 1 year old. Never give even just a little taste on a pacifier.

Help prevent infant botulism by breastfeeding only, if possible.

Always throw away bulging cans or foul-smelling preserved foods. Sterilize home-canned foods by pressure cooking them at 250°F (121°C) for 30 minutes. This can reduce the risk for botulism.

See the Centers for Disease Control and Prevention website for more information on home canning safety at www.cdc.gov/foodsafety/communication/home-canning-and-botulism.html.

Keep foil-wrapped baked potatoes hot or in the refrigerator. Do not store at room temperature. Carrot juice and oils with garlic or other herbs should also be refrigerated. Make sure to set the refrigerator temperature at 40°F (10°C) or lower.

What are the latest Botulism Clinical Trials?
Pharmacokinetics of Botulism Antitoxin Heptavalent (A, B, C, D, E, F, G) - (Equine) (BAT®) in Pediatric Patients With a Confirmed or Suspected Exposure to Botulinum Neurotoxin
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Botulinum Toxin for the Treatment of Neurological Disorders
What are the Latest Advances for Botulism?
OnabotulinumtoxinA for the treatment of headache: an updated review.
Learning from Nature: Bacterial Spores as a Target for Current Technologies in Medicine (Review).
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Botulinum Toxin: From Poison to Possible Treatment for Spasticity in Spinal Cord Injury.
Who are the sources who wrote this article ?

Published Date : September 01, 2021
Published By : Jatin M. Vyas, MD, PhD, Associate Professor in Medicine, Harvard Medical School; Associate in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Birch TB, Bleck TP. Botulism (Clostridium botulinum). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 245.

Norton LE, Schleiss MR. Botulism (Clostridium botulinum). In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 237.