Association Between Immune Status and Disease Control in Patients With Inflammatory Airway Diseases
The goal of this study is to learn how the body's immune system affects disease control in people with different airway inflammatory diseases.We want to understand: 1.Whether specific immune cell patterns in the blood are linked to how severe the disease is or how well it is controlled. Participants will: 1. Answer questions about their health and symptoms. 2. Give blood samples 3. Have lung function tests and other standard check-ups. 4. share sleep study results. We will compare people with airway diseases to healthy volunteers to see how their immune systems differ.
• Age ≥18 years (≥40 years for COPD patients).
• Clinical diagnosis of asthma, ABPA, bronchiectasis, OSAS, or COPD according to established criteria.
• PRISm patients (post-BD FEV1/FVC ≥70% and FEV1 \<80% predicted)
• Smoking controls: ≥10 pack-years, normal lung function, no chronic respiratory symptoms.
• Healthy controls: normal lung function, FeNO \<20 ppb, total IgE \<100 IU/mL, no chronic disease, smoking \<10 pack-years, no immunosuppressant use within 3 months.