Feasibility and Safety of Duodenal Feeds in Very Low Birth Weight Infants

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Premature infants have high rates of bronchopulmonary dysplasia (BPD) due to prematurity of the participants' lungs and the need for prolonged respiratory support. These infants are at increased risk for gastroesophageal reflux and aspiration which may exacerbate lung injury. Transpyloric feeds, specifically duodenal feeds, may be used to bypass the stomach and directly feed the duodenum decreasing the amount of gastric reflux contributing to aspiration. Duodenal feeds are equivalent to gastric feeds with regards to nutritional outcomes, and have been shown to decrease events of apnea and bradycardia in premature infants. This study will evaluate the feasibility and safety of duodenal feeds in premature infants. The hypothesis is that duodenal feeds may be safely and successfully performed in premature very low birth weight infants.

Eligibility
Participation Requirements
Sex: All
Maximum Age: 1
Healthy Volunteers: t
View:

• Infants admitted to the Johns Hopkins All Children's NICU before 72 hours of life

• Infants with a birth weight \<1251g

Locations
United States
Florida
Johns Hopkins All Children's Hospital
RECRUITING
St. Petersburg
Contact Information
Primary
Noura Nickel, MD
nnickel1@jh.edu
727-767-4313
Time Frame
Start Date: 2020-08-07
Estimated Completion Date: 2026-03-31
Participants
Target number of participants: 30
Treatments
No_intervention: Gastric Feeds
Patients in this arm will receive feeds via the standard route which is gastric feeds.
Experimental: Duodenal Feeds
Patients in this arm will receive feeds via the experimental route which is duodenal feeds.
Authors
Sponsors
Leads: Johns Hopkins All Children's Hospital

This content was sourced from clinicaltrials.gov