Risk Factor Analysis Study for the Efficacy Comparison Between Advanced Immunochemotherapy and Classical Immunochemotherapy: a Prospective Study for Relapsed/Refractory Lymphoma Patients

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Drug
Study Type: Observational
SUMMARY

The goal of this observational study is to compare the efficacy of advanced immunochemotherapy and classical immunochemotherapy in relapsed/refractory high grade B cell lymophoma patients. The main question it aims to answer is: Does advanced immunochemotherapy, including CAR-T therapy, bispecific antibody, and antibody-drug conjugate offer superior survival outcomes than when treated with classical immunochemotherapy, such as proteasome inhibitors, immune modulatory drugs, and monoclonal antibodies? Researchers will compare patients receiving advanced immunochemotherapy with those receiving classical immunochemotherapy to determine if advanced therapies result in better survival outcomes. Laboratory findings and electronic medical records (EMR) from participants will be used to assess survival outcomes and treatment-related safety profiles.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 19
Maximum Age: 74
Healthy Volunteers: f
View:

• Adults aged 19 to 74 years.

• Diagnosed with any of the following after January 2015: diffuse large B cell lymphoma, primary mediastinal large B cell lymphoma, high grade B cell lymphoma, or Burkitt lymphoma

• Patients who have received immunochemotherapy as treatment for relapsed/refractory lymphoma

Locations
Other Locations
Republic of Korea
Seoul St. Mary Hospital
RECRUITING
Seoul
Yeoido St. Mary Hospital
RECRUITING
Seoul
Contact Information
Primary
Sung-Soo Park, MD. PhD.
sspark@catholic.ac.kr
+82-02-2258-6754
Backup
Young-Woo Jeon, MD. PhD.
native47@catholic.ac.kr
+82-10-2691-4067
Time Frame
Start Date: 2024-06-26
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 72
Treatments
Advanced immunochemotherapy
Relapsed/refractory high grade B cell lymphoma patients treated with either chimeric antigen receptor T cell therapy, bispecific antibody, or antibody-drug conjugate
Classical Immunochemotherapy
Relapsed/refractory high grade B cell lymphoma patients treated with either proteasome inhibitor, immune modulatory drug, or monoclonal antibody.
Sponsors
Collaborators: Yeouido St. Mary's Hospital
Leads: Sung-Soo Park

This content was sourced from clinicaltrials.gov

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