Calcium Pyrophosphate Arthritis Overview
Learn About Calcium Pyrophosphate Arthritis
View Main Condition: Arthritis
Calcium pyrophosphate dihydrate (CPPD) arthritis is a joint disease that can cause attacks of arthritis. Like gout, crystals form in the joints. But in this arthritis, the crystals are not formed from uric acid.
Calcium pyrophosphate dihydrate deposition disease; CPPD disease; Acute/chronic CPPD arthritis; Pseudogout; Pyrophosphate arthropathy; Chondrocalcinosis
Deposition of calcium pyrophosphate dihydrate (CPPD) causes this form of arthritis. The buildup of this chemical forms crystals in the cartilage of joints. This leads to attacks of joint swelling and pain most often in the knees, wrists, ankles, and shoulders. Other joints can be affected as well. In contrast to gout, the metatarsal-phalangeal joint of the big toe is not affected.
Among older adults, CPPD is a common cause of sudden (acute) arthritis in one joint. The attack may be caused by:
- Injury to the joint
- Medical stress
CPPD arthritis mainly affects the elderly because joint degeneration and osteoarthritis increases with age. Such joint damage increases the tendency of CPPD deposition. However, CPPD arthritis is also more common in people with:
- Hemochromatosis
- Parathyroid gland disease
- Dialysis-dependent renal failure
In most cases, CPPD deposits do not cause any symptoms. Instead, x-rays of affected joints such as knees show characteristic deposits of calcium.
Some people with chronic CPPD deposits in large joints may have the following symptoms:
- Pain
- Swelling
- Warmth
- Redness
Attacks of joint pain can last for months. There may be no symptoms between attacks.
In some people CPPD arthritis causes severe damage to a joint.
CPPD arthritis can also occur in the upper and lower spine. Pressure on spinal nerves may cause pain in the arms or legs.
Because the symptoms are similar, CPPD arthritis can be confused with:
- Gouty arthritis (gout)
- Osteoarthritis
- Rheumatoid arthritis
Treatment may involve removing fluid to relieve pressure in the joint. A needle is placed into the joint and fluid is aspirated. Some common treatment options are:
- Steroid injections: to treat severely swollen joints
- Oral steroids: to treat multiple swollen joints
- Nonsteroidal anti-inflammatory medicines (NSAIDs): to ease the pain
- Colchicine: to treat attacks of CPPD arthritis
- For chronic CPPD arthritis in multiple joints, methotrexate or hydroxychloroquine may be helpful
Northern Arizona Healthcare Corporation
Brian Duggan is an Orthopedics provider in Cottonwood, Arizona. Dr. Duggan and is rated as an Advanced provider by MediFind in the treatment of Calcium Pyrophosphate Arthritis. His top areas of expertise are Osteoarthritis, Tendinitis, Calcium Pyrophosphate Arthritis, Tenosynovitis, and Hip Replacement. Dr. Duggan is currently accepting new patients.
Mori Bean And Brooks Inc
Alan Ericksen is a Radiologist in Sedona, Arizona. Dr. Ericksen and is rated as an Experienced provider by MediFind in the treatment of Calcium Pyrophosphate Arthritis. His top areas of expertise are Saddle Pulmonary Embolism, Vertigo, Chronic Cough, and Pleurisy. Dr. Ericksen is currently accepting new patients.
Northern Arizona Healthcare Corporation
Adam Schneider is an Orthopedics specialist and a Hand Surgeon in Cottonwood, Arizona. Dr. Schneider and is rated as an Experienced provider by MediFind in the treatment of Calcium Pyrophosphate Arthritis. His top areas of expertise are Carpal Tunnel Syndrome, Rhizarthrosis, Osteoarthritis, Ganglion Cyst, and Hip Replacement. Dr. Schneider is currently accepting new patients.
Most people do well with treatment to reduce the acute joint pain. A medicine such as colchicine may help prevent repeat attacks. There is no treatment to remove the CPPD crystals.
Permanent joint damage can occur without treatment.
Contact your provider if you have attacks of joint swelling and joint pain.
There is no known way to prevent this disorder. However, treating other problems that may cause CPPD arthritis may make the condition less severe.
Regular follow-up visits may help prevent permanent damage of the affected joints.
Summary: The objectives of this study are the assessment of the clinical, radiographical and patient-reported outcomes of SMR Stemless Reverse Shoulder Arthroplasty (LimaCorporate S.p.A.) used as standard of care over a period of at least 2 years of follow-up and the evaluation of the incidence of any complication.
Summary: The objective of this research is to collect data to create an observatory of microcrystalline rheumatism (gout and calcium-crystal rheumatism) in patients treated at the Groupement des Hôpitaux de l'Institut Catholique de Lille, in order to better understand the disease and improve patient care, in particular with the help of medical imaging.
Published Date: March 31, 2024
Published By: Neil J. Gonter, MD, Assistant Professor of Medicine, Columbia University, NY and private practice specializing in Rheumatology at Rheumatology Associates of North Jersey, Teaneck, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Edwards NL. Crystal deposition diseases. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 252.
Terkeltaub R. Calcium crystal disease: calcium pyrophosphate dihydrate and basic calcium phosphate. In: Firestein GS, Budd RC, Gabriel SE, Koretzky GA, McInnes IB, O'Dell JR, eds. Firestein & Kelley's Textbook of Rheumatology. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 102.