The Prevalence and Significance of Low QRS Voltages in Young Healthy Individuals and Athletes

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

There is some limited evidence that reduced size of electrical complexes/traces of the heart on the electrocardiogram (ECG) may be associated with scarring in the heart muscle, which may predispose to serious life-threatening electrical abnormalities and sudden cardiac death (SCD). There is no current guidance on how young individuals and athletes with reduced ECG traces should be managed. Therefore, correct interpretation of this ECG finding is crucial for identifying athletes with disease and at risk of SCD. Some athletes experience SCD despite normal standard cardiac tests. The investigators, therefore, propose to study young healthy individuals and young athletes using cardiovascular MRI, cardiopulmonary exercise testing, 24 hour ECG monitoring and genetic analysis to determine the significance of reduced ECG traces and possibly revise current international sports recommendations.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 17
Maximum Age: 35
Healthy Volunteers: t
View:

• No cardiovascular symptoms

• Body mass index \<30.

Locations
Other Locations
United Kingdom
Royal Brompton Hospital
RECRUITING
London
Contact Information
Primary
Sabiha Gati, MBBS
s.gati@rbht.nhs.uk
07977 352296
Backup
Nirmitha Jayaratne-Sandhu, MBBS
n.jayaratne@rbht.nhs.uk
07977 352296
Time Frame
Start Date: 2023-10-09
Estimated Completion Date: 2025-11-01
Participants
Target number of participants: 240
Treatments
Athletes with low QRS voltage
Cohort (anticipated N = 60) will undergo testing with 12 lead ECG, blood test, cardiac MRI, 24 hour holter monitoring and cardiopulmonary exercise testing.~A subgroup of those identified to have low QRS voltage and myocardial scar on CMR will undergo genetic testing (anticipated number to be tested, N= 25)
Young healthy individuals (non-athletes) with low QRS voltage
Cohort (anticipated N = 60) will undergo testing with 12 lead ECG, blood test, cardiac MRI, 24 hour holter monitoring and cardiopulmonary exercise testing.~A subgroup of those identified to have low QRS voltage and myocardial scar on CMR will undergo genetic testing (anticipated number to be tested, N= 25)
Age and sex matched control group of athletes with normal QRS voltage
Cohort (anticipated N = 60) will undergo testing with 12 lead ECG, blood test, cardiac MRI, 24 hour holter monitoring and cardiopulmonary exercise testing.
Age and sex matched young healthy controls (non-athletes) with normal QRS voltage
Cohort (anticipated N = 60) will undergo testing with 12 lead ECG, blood test, cardiac MRI, 24 hour holter monitoring and cardiopulmonary exercise testing.
Sponsors
Collaborators: Royal Brompton & Harefield NHS Foundation Trust, Cardiac Risk in the Young, St George's, University of London
Leads: Imperial College London

This content was sourced from clinicaltrials.gov