Early Amiodarone in Shockable Cardiac Arrest (Early-Amio) Study

Status: Recruiting
Location: See location...
Intervention Type: Drug, Other
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

The primary objective of this pilot, pragmatic stepped-wedge cluster randomized trial is to evaluate if a modified cardiac arrest treatment algorithm calling for the administration of the initial amiodarone dose one 2-minute cycle earlier than current guidelines (during the same cycle as the initial dose of epinephrine) improves the time to amiodarone delivery in those with out-of-hospital cardiac arrest due to refractory ventricular fibrillation or ventricular tachycardia compared to usual care.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Emergency medical services (EMS)-treated non-traumatic out-of-hospital cardiac arrest

• Initial rhythm on EMS rhythm assessment of ventricular fibrillation or ventricular tachycardia

• Recurrence or persistence of ventricular fibrillation or ventricular tachycardia after one defibrillation attempt

Locations
United States
Oregon
Oregon Health & Sciences University
RECRUITING
Portland
Contact Information
Primary
Joshua Lupton, MD, MPH
lupton@ohsu.edu
(503) 418-6706
Time Frame
Start Date: 2025-01-01
Estimated Completion Date: 2028-01-31
Participants
Target number of participants: 585
Treatments
Experimental: Early Amiodarone Protocol
Amiodarone administration after the second defibrillator shock, during the same two-minute cycle as the initial dose of epinephrine.
Active_comparator: Usual Care Protocol
Amiodarone administration after the third defibrillator shock, one two-minute cycle after the initial dose of epinephrine.
Sponsors
Collaborators: National Heart, Lung, and Blood Institute (NHLBI)
Leads: Oregon Health and Science University

This content was sourced from clinicaltrials.gov

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