Peri-Arrest Ventilation With Positive End-Expiratory-Pressure vs. Zero End-Expiratory-Pressure in Out-of-Hospital-Cardiac-Arrest
Status: Recruiting
Location: See all (3) locations...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge. Despite the frequent use of airway management and mechanical ventilation during resuscitation, there is limited evidence regarding the optimal ventilation strategy to improve oxygen delivery and patient outcomes. The present study aims to investigate the effects of positive-end-expiratory-pressure (PEEP) set at 5 mbar compared to zero-end-expiratory-pressure (ZEEP) on the return of spontaneous-circulation (ROSC) in adult patients with OHCA.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Adults \>= 18 years
• non-traumatic OHCA
• mechanical ventilation via airway device
Locations
Other Locations
Germany
Emergency Medical Services
RECRUITING
Gütersloh
JWK Minden
RECRUITING
Minden
Emergency Medical Services
RECRUITING
Osnabrück
Contact Information
Primary
Gerrit Jansen, PD Dr. med.
gerrit.jansen@muehlenkreiskliniken.de
+49 571-790-54401
Backup
Jochen Hinkelbein, Prof. Dr. med.
jochen.hinkelbein@muehlenkreiskliniken.de
+49 571-790-54401
Time Frame
Start Date: 2025-06-01
Estimated Completion Date: 2026-10-31
Participants
Target number of participants: 600
Treatments
Experimental: PEEP
PEEP Group (Intervention Group): Patients will receive mechanical ventilation with end-expiratory-pressure set at 5 mbar (PEEP).
Experimental: ZEEP
ZEEP Group (Control Group): Patients will receive mechanical ventilation with end-expiratory-pressure set at 0 mbar (ZEEP).
Related Therapeutic Areas
Sponsors
Leads: Muehlenkreiskliniken, MKK