Long-Term Observational Extension of Participants in the CREST-2 Randomized Clinical Trial
Status: Enrolling_by_invitation
Location: See all (64) locations...
Intervention Type: Procedure, Other
Study Type: Observational
SUMMARY
The purpose of this Long-Term Observational Extension of Participants in the CREST-2 Randomized Clinical Trial (C2LOE - ClinicalTrials.gov Identifier: NCT02089217) study is to study is to assess post-procedural efficacy of carotid endarterectomy and carotid stenting.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 35
Healthy Volunteers: f
View:
• Currently active or graduated participants in the CREST-2 randomized trial
• Able to provide written informed consent by self
• Fluent in English or Spanish
Locations
United States
Alabama
University of Alabama at Birmingham
Birmingham
Arkansas
Central Arkansas VA
Little Rock
Arizona
Mayo Clinic Pheonix
Phoenix
Banner University Medical Center
Tucson
California
Mission Cardiovascular Research Institute
Fremont
Kaiser Permanente Los Angeles
Los Angeles
University of California Los Angeles
Los Angeles
USC/Keck Medical Center
Los Angeles
Kaiser Permanente Divsion of Research
San Francisco
Kaiser Permanente San Francisco
San Francisco
St. Joseph's Medical Center
Stockton
Connecticut
Hartford Hospital
Hartford
Yale New Haven Hospital
New Haven
Florida
Morton Plant Mease Healthcare
Clearwater
University of Florida Health at Shands
Gainesville
Lyerly Neurosurgery/Baptist Health
Jacksonville
Mayo Clinic Jacksonville
Jacksonville
University of Florida Jacksonville
Jacksonville
Miami Cardiac and Vascular Institute
Miami
Cardiovascular Institute NW Florida
Panama City
Iowa
University of Iowa Hospitals & Clinics
Iowa City
Illinois
University of Chicago Medical Center
Chicago
Endeavor Health/NorthShore University
Evanston
Prairie Heart/St. John's Hospital
Springfield
Indiana
Deaconess Heart Group
Newburgh
Kentucky
Baptist Health
Lexington
Louisiana
Ochsner Health System
New Orleans
Massachusetts
Massachusetts General Hospital
Boston
St. Elizabeth's Medical Center
Boston
Maryland
Johns Hopkins University
Baltimore
VA Medical Center
Baltimore
White Oak Medical Center
Silver Spring
Maine
Maine Medical Center
Portland
Michigan
VA Ann Arbor
Ann Arbor
Henry Ford Health System
Detroit
Michigan Vascular Center
Flint
Sparrow Clinical Research Institute
Lansing
Michigan Heart
Ypsilanti
Minnesota
North Memorial Medical Center
Golden Valley
Mayo Clinic Rochester
Rochester
Missouri
Mercy Hospital
St Louis
North Carolina
Duke University Medical Center
Durham
Wake Forest Baptist Health
Winston-salem
New York
SUNY Buffalo
Buffalo
Weill Cornell Medical College
New York
Crouse Hospital
Syracuse
Ohio
Mercy Health St. Vincent
Toledo
Oregon
Oregon Health & Science University
Portland
Pennsylvania
Pinnacle Health
Harrisburg
Hospital of University of Pennsylvania
Philadelphia
VA Pittsburgh
Pittsburgh
Berks Cardiologists
Wyomissing
Rhode Island
The Miriam Hospital
Providence
Tennessee
Wellmont CVA Heart Institute
Kingsport
Tennova Healthcare
Knoxville
Texas
Seton Medical Center
Austin
Utah
University of Utah Hospitals & Clinics
Salt Lake City
Virginia
University of Virginia
Charlottesville
Inova Fairfax Hospital
Falls Church
Washington
VA Puget Sound
Seattle
Wisconsin
Gundersen Clinic, Ltd.
La Crosse
Other Locations
Canada
Nova Scotia Health Authority
Halifax
Vancouver General Hospital
Vancouver
Spain
Hospital Clinic of Barcelona
Barcelona
Time Frame
Start Date: 2022-07-05
Completion Date: 2026-02-28
Participants
Target number of participants: 2480
Treatments
Carotid Stenting Group (CAS)
Subjects assigned to the intensive medical management with carotid stenting group in the CREST-2 study (NCT02089217)
Carotid Endarterectomy Group (CEA)
Subjects assigned to the intensive medical management with carotid endarterectomy group in the CREST-2 study (NCT02089217)
Intensive Medical Management Group - no CAS
Subjects assigned to the intensive medical management alone with no carotid stenting (CAS) group in the CREST-2 study (NCT02089217)
Intensive Medical Management Group - no CEA
Subjects assigned to the intensive medical management alone with no carotid endarterectomy (CEA) group in the CREST-2 study (NCT02089217)
Related Therapeutic Areas
Sponsors
Leads: Mayo Clinic
Collaborators: Medical University of South Carolina, University of Maryland, University of Alabama at Birmingham, National Institute of Neurological Disorders and Stroke (NINDS)