Clinical Analysis and Ultrasound Evaluation of the Median Nerve Cross-sectional Area Before and After Carpal Tunnel Release

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY

Carpal Tunnel Syndrome (CTS) is a common condition where pressure on the median nerve in the wrist causes pain, numbness, and weakness in the hand. Surgery to release the carpal tunnel is often performed to relieve these symptoms. This study will evaluate the changes in the median nerve after surgery and how these changes relate to symptom improvement. Investigators will use ultrasound imaging to measure the nerve size before and at three and six months after surgery. Patients will also complete questionnaires about their symptoms and hand function, and undergo tests to assess strength and sensation. The investigator's goal is to determine whether changes observed on ultrasound are associated with the rate of patient recovery. This may help doctors better monitor healing and improve care for people with CTS.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Clinical diagnosis of primary carpal tunnel syndrome (CTS), confirmed by characteristic symptoms, physical examination findings, and a cross-sectional area superior to 10 mm² in the ultrasonography baseline.

• Indication for open carpal tunnel release as part of routine clinical care.

Locations
Other Locations
Brazil
Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da FMUSP
RECRUITING
São Paulo
Contact Information
Primary
Joao Carlos Rodrigues, MD, PhD
joao.r@hc.fm.usp.br
+55112661-6909
Backup
Marcelo Rosa Rezende, MD, PhD
marcelo.rezende@ hc.fm.usp.br
+55112661-6909
Time Frame
Start Date: 2025-06-25
Estimated Completion Date: 2028-12-31
Participants
Target number of participants: 106
Treatments
Surgical Cohort
Patients diagnosed with primary carpal tunnel syndrome (CTS) are undergoing open carpal tunnel release as part of their routine clinical care. The surgical procedure is not assigned by the study but performed according to standard practice. The cohort will be followed prospectively with clinical assessments (Boston Carpal Tunnel Questionnaire, QuickDASH, grip and pinch strength, Semmes-Weinstein monofilament testing), as well as ultrasonographic evaluation of the median nerve cross-sectional area, before and at three and six months after surgery, to identify prognostic factors associated with functional and symptomatic recovery.
Sponsors
Leads: University of Sao Paulo General Hospital

This content was sourced from clinicaltrials.gov