Chronic B-Cell Leukemia (CBCL)
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Chronic B-Cell Leukemia (CBCL) Overview

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Learn About Chronic B-Cell Leukemia (CBCL)

View Main Condition: Leukemia

What is the definition of Chronic B-Cell Leukemia (CBCL)?
Chronic B cell leukemia is a type of chronic lymphocytic leukemia (CLL), or cancer of the blood and bone marrow that mainly affects adults. In chronic B cell leukemia, the bone marrow produces too many B lymphocytes, which are white blood cells that fight infection. Chronic B cell leukemia represents 95% of all chronic lymphocytic leukemias.
What are the symptoms of Chronic B-Cell Leukemia (CBCL)?
Individuals with early chronic B cell leukemia may not have any symptoms. Symptoms of intermediate and advanced stage chronic B cell leukemia may include painless, enlarged lymph nodes; fatigue; fever; pain in the upper left region of the abdomen; enlarged spleen; easy bruising or bleeding; pinpoint, dark red spots under the skin (petechiae); night sweats; weight loss; and frequent infections.
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What are the current treatments for Chronic B-Cell Leukemia (CBCL)?
Treatment for chronic B cell leukemia depends on the stage. Early stage chronic B cell leukemia may not need treatment and may involve watchful waiting. Treatment for intermediate and advanced stages chronic B cell leukemia may include targeted therapy, chemotherapy, radiation therapy, immunotherapy, and bone marrow or peripheral stem cell transplant.
Who are the top Chronic B-Cell Leukemia (CBCL) Local Doctors?
Elite in Chronic B-Cell Leukemia (CBCL)
Elite in Chronic B-Cell Leukemia (CBCL)
Referral may be required

CUIMC/Herbert Irving Pavilion

161 Fort Washington Avenue, 
New York, NY 
212-305-5098
Languages Spoken:
English
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Accepting New Patients
Offers Telehealth

Nicole Lamanna is an Oncologist practicing medicine in New York, New York. Dr. Lamanna is rated as an Elite provider by MediFind in the treatment of Chronic B-Cell Leukemia (CBCL). She is also highly rated in 17 other conditions, according to our data. Her clinical expertise encompasses Chronic B-Cell Leukemia (CBCL), Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL), Bone Marrow Aspiration, and Gastrostomy. Dr. Lamanna is board certified in Medical Oncology. Dr. Lamanna is currently accepting new patients.

Elite in Chronic B-Cell Leukemia (CBCL)
Elite in Chronic B-Cell Leukemia (CBCL)
Referral may be required

Duke University Health System Inc

20 Duke Medicine Cir, 
Durham, NC 
919-684-8111
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Danielle Brander is an Oncologist practicing medicine in Durham, North Carolina. Dr. Brander is rated as an Elite provider by MediFind in the treatment of Chronic B-Cell Leukemia (CBCL). She is also highly rated in 10 other conditions, according to our data. Her clinical expertise encompasses Chronic Lymphocytic Leukemia (CLL), Chronic B-Cell Leukemia (CBCL), Small Lymphocytic Lymphoma (SLL), Leukemia, and Bone Marrow Aspiration. Dr. Brander is currently accepting new patients.

 
 
 
 
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Elite in Chronic B-Cell Leukemia (CBCL)
Elite in Chronic B-Cell Leukemia (CBCL)
Referral may be required

Regents Of The University Of California

9400 Campus Point Dr, 
La Jolla, CA 
858-822-6100
Languages Spoken:
English
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Offers Telehealth

Thomas Kipps is a Hematologist practicing medicine in La Jolla, California. Dr. Kipps is rated as an Elite provider by MediFind in the treatment of Chronic B-Cell Leukemia (CBCL). He is also highly rated in 10 other conditions, according to our data. His clinical expertise encompasses Chronic B-Cell Leukemia (CBCL), Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL), and Leukemia.

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What are the latest Chronic B-Cell Leukemia (CBCL) Clinical Trials?
A Phase III, Randomised, Open-label, Multicentre, Study of Surovatamig as Consolidation Therapy Versus Observation After First-line Induction Therapy in Participants With Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated IGHV (SOUNDTRACK-C1)
A Phase III, Randomised, Open-label, Multicentre, Study of Surovatamig as Consolidation Therapy Versus Observation After First-line Induction Therapy in Participants With Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated IGHV (SOUNDTRACK-C1)
Enrollment Status: Recruiting
Publish Date: September 08, 2026
Intervention Type: Drug
Study Phase: Phase 3

Summary: The purpose of this study is to evaluate the therapeutic benefit and safety of subcutaneous (SC) Surovatamig monotherapy as consolidation therapy in patients with Chronic Lymphocytic Leukaemia (CLL)/ Small Lymphocytic Lymphoma (SLL) with unmutated IGHV (uIGHV).

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A Phase IB Open-Label, Multicenter Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab and a Combined Regimen of Mosunetuzumab and Venetoclax in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia
A Phase IB Open-Label, Multicenter Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab and a Combined Regimen of Mosunetuzumab and Venetoclax in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia
Who is this study for: Patients with relapsed or refractory chronic lymphocytic leukemia
Enrollment Status: Recruiting
Publish Date: September 08, 2026
Intervention Type: Drug
Study Drugs: Mosunetuzumab, Tocilizumab
Study Phase: Phase 1

Summary: This study will assess the safety, tolerability, pharmaokinetics, and preliminary efficacy of mosunetuzumab (Lunsumio) monotherapy in participants with relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). This study will also allow participants who are currently progressing on a Bruton tyrosine kinase inhibitor (BTKi) and requiring salvage therapy as...

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