Chronic B-Cell Leukemia (CBCL)
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Learn About Chronic B-Cell Leukemia (CBCL)

View Main Condition: Leukemia

What is the definition of Chronic B-Cell Leukemia (CBCL)?
Chronic B cell leukemia is a type of chronic lymphocytic leukemia (CLL), or cancer of the blood and bone marrow that mainly affects adults. In chronic B cell leukemia, the bone marrow produces too many B lymphocytes, which are white blood cells that fight infection. Chronic B cell leukemia represents 95% of all chronic lymphocytic leukemias.
What are the symptoms of Chronic B-Cell Leukemia (CBCL)?
Individuals with early chronic B cell leukemia may not have any symptoms. Symptoms of intermediate and advanced stage chronic B cell leukemia may include painless, enlarged lymph nodes; fatigue; fever; pain in the upper left region of the abdomen; enlarged spleen; easy bruising or bleeding; pinpoint, dark red spots under the skin (petechiae); night sweats; weight loss; and frequent infections.
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What are the current treatments for Chronic B-Cell Leukemia (CBCL)?
Treatment for chronic B cell leukemia depends on the stage. Early stage chronic B cell leukemia may not need treatment and may involve watchful waiting. Treatment for intermediate and advanced stages chronic B cell leukemia may include targeted therapy, chemotherapy, radiation therapy, immunotherapy, and bone marrow or peripheral stem cell transplant.
Who are the top Chronic B-Cell Leukemia (CBCL) Local Doctors?
Elite in Chronic B-Cell Leukemia (CBCL)
Hematology Oncology | Hematology | Oncology
Elite in Chronic B-Cell Leukemia (CBCL)
Hematology Oncology | Hematology | Oncology
Referral may be required

Northwell Health Center For Advanced Medicine, RJ Zuckerberg Cancer Center

450 Lakeville Road, Entrance B, 
Lake Success, NY 
Languages Spoken:
English

The Chronic Lymphocytic Leukemia (CLL) Research and Treatment Program has become a landmark for CLL patients worldwide. Dr. Kanti Rai has been involved in diagnosing and treating CLL for almost 40 years and the staging system that bears his name came out of his early breakthrough research. His particular areas of interest are: natural history of CLL, improving prognostic features of this disease and developing newer strategies of therapy which are hypothesis-driven. Dr. Rai is an active member of the International Workshop on CLL (iwCLL) and Dr. Keating s Global CLL Foundation. He is an active member of the American Society of Clinical Oncology (ASCO), American Association for Cancer Research (AACR) and the American Society of Hematology (ASH). In 2006, Dr. Rai served as the President of ASH. He was the recipient of ASCO s David Karnofsky Memorial Award in 2012. In 2013, Dr. Rai was honored with the iwCLL David Galton award. In 2014 he was presented with ASH s Wallace H. Coulter Lifetime Achievement Award. Dr. Rai is the Joel Finkelstein Cancer Foundation Professor of Medicine, and Professor of Molecular Medicine at the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell School of Medicine and Professor of Medicine at the Feinstein Institute for Medical Research, Manhasset, NY. Dr. Rai is rated as an Elite provider by MediFind in the treatment of Chronic B-Cell Leukemia (CBCL). He is also highly rated in 7 other conditions, according to our data. His clinical expertise encompasses Chronic B-Cell Leukemia (CBCL), Chronic Lymphocytic Leukemia (CLL), Leukemia, and Richter Syndrome. Dr. Rai is board certified in American Board Of Pediatrics.

Elite in Chronic B-Cell Leukemia (CBCL)
Hematology Oncology | Hematology | Oncology
Elite in Chronic B-Cell Leukemia (CBCL)
Hematology Oncology | Hematology | Oncology
Referral may be required

Cleveland Clinic Main Campus

10201 Carnegie Avenue, 
Cleveland, OH 
Experience:
30+ years
Languages Spoken:
English
Offers Telehealth

Brian Hill is a Hematologist Oncology specialist and a Hematologist practicing medicine in Cleveland, Ohio. He has been practicing medicine for over 30 years. Dr. Hill is rated as an Elite provider by MediFind in the treatment of Chronic B-Cell Leukemia (CBCL). He is also highly rated in 30 other conditions, according to our data. His clinical expertise encompasses Non-Hodgkin Lymphoma, B-Cell Lymphoma, Diffuse Large B-Cell Lymphoma (DLBCL), Bone Marrow Transplant, and Bone Marrow Aspiration.

 
 
 
 
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Elite in Chronic B-Cell Leukemia (CBCL)
Elite in Chronic B-Cell Leukemia (CBCL)
Referral may be required

Abramson Cancer Center Perelman 4th Floor West

3400 Civic Center Boulevard, West Pavilion, 4th Floor, 
Philadelphia, PA 
Languages Spoken:
English
Offers Telehealth

Stephen Schuster is a Hematologist practicing medicine in Philadelphia, Pennsylvania. Dr. Schuster is rated as an Elite provider by MediFind in the treatment of Chronic B-Cell Leukemia (CBCL). He is also highly rated in 26 other conditions, according to our data. His clinical expertise encompasses Non-Hodgkin Lymphoma, B-Cell Lymphoma, Follicular Lymphoma, Bone Marrow Transplant, and Bone Marrow Aspiration. Dr. Schuster is board certified in Medical Oncology, 1989, Hematology, 1986, and Internal Medicine, 1984.

What are the latest Chronic B-Cell Leukemia (CBCL) Clinical Trials?
Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL)

Eligibility: * Diagnosis of CLL/SLL and on treatment/previously treated/nearing treatment * Diagnosis of LPL/WM * As of February 5, 2025, patients with MBL and SMZL will no longer be enrolled. * Age greater than or equal to 18 years. * ECOG performance status of 0-2. Design Patients are typically followed every 6 to 24 months in the clinic and have blood drawn. Patients may be asked to undergo additional testi...

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A Phase 1/2, Open-Label, Dose-Escalation and -Expansion Study of the Bruton Tyrosine Kinase Targeted Protein Degrader BGB-16673 in Patients With B-Cell Malignancies

Summary: Study consists of two main parts to explore BGB-16673 recommended dosing, a Phase 1 monotherapy dose finding comprised of monotherapy dose escalation and monotherapy safety expansion of selected doses, and a Phase 2 (expansion cohorts)