Chronic B-Cell Leukemia (CBCL) Overview

Save information for later
Sign Up

Learn About Chronic B-Cell Leukemia (CBCL)

View Main Condition: Leukemia

What is the definition of Chronic B-Cell Leukemia (CBCL)?
Chronic B cell leukemia is a type of chronic lymphocytic leukemia (CLL), or cancer of the blood and bone marrow that mainly affects adults. In chronic B cell leukemia, the bone marrow produces too many B lymphocytes, which are white blood cells that fight infection. Chronic B cell leukemia represents 95% of all chronic lymphocytic leukemias.
What are the symptoms of Chronic B-Cell Leukemia (CBCL)?
Individuals with early chronic B cell leukemia may not have any symptoms. Symptoms of intermediate and advanced stage chronic B cell leukemia may include painless, enlarged lymph nodes; fatigue; fever; pain in the upper left region of the abdomen; enlarged spleen; easy bruising or bleeding; pinpoint, dark red spots under the skin (petechiae); night sweats; weight loss; and frequent infections.
Not sure about your diagnosis?
Check Your Symptoms
What are the current treatments for Chronic B-Cell Leukemia (CBCL)?
Treatment for chronic B cell leukemia depends on the stage. Early stage chronic B cell leukemia may not need treatment and may involve watchful waiting. Treatment for intermediate and advanced stages chronic B cell leukemia may include targeted therapy, chemotherapy, radiation therapy, immunotherapy, and bone marrow or peripheral stem cell transplant.
Who are the top Chronic B-Cell Leukemia (CBCL) Local Doctors?
Danielle M. Brander
Elite in Chronic B-Cell Leukemia (CBCL)
Dr. Danielle M. Brander
Hematology Oncology | Hematology | Oncology
Elite in Chronic B-Cell Leukemia (CBCL)
Dr. Danielle M. Brander
Hematology Oncology | Hematology | Oncology

Duke Health Integrated Practice Inc

2351 Erwin Rd, 
Durham, NC 
919-684-8111
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Danielle Brander is a Hematologist Oncology specialist and a Hematologist in Durham, North Carolina. Dr. Brander is rated as an Elite provider by MediFind in the treatment of Chronic B-Cell Leukemia (CBCL). Her top areas of expertise are Chronic Lymphocytic Leukemia (CLL), Chronic B-Cell Leukemia (CBCL), Small Lymphocytic Lymphoma (SLL), Leukemia, and Bone Marrow Aspiration. Dr. Brander is currently accepting new patients.

Elite in Chronic B-Cell Leukemia (CBCL)
Dr. Thomas J. Kipps
Hematology Oncology | Oncology | Hematology
Elite in Chronic B-Cell Leukemia (CBCL)
Dr. Thomas J. Kipps
Hematology Oncology | Oncology | Hematology

Regents Of The University Of California

200 W Arbor Dr, 
San Diego, CA 
858-657-7000
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Thomas Kipps is a Hematologist Oncology specialist and an Oncologist in San Diego, California. Dr. Kipps is rated as an Elite provider by MediFind in the treatment of Chronic B-Cell Leukemia (CBCL). His top areas of expertise are Chronic B-Cell Leukemia (CBCL), Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL), and Leukemia.

 
 
 
 
Learn about our expert tiers
Learn More
Elite in Chronic B-Cell Leukemia (CBCL)
Dr. Nicole Lamanna
Oncology | Hematology
Elite in Chronic B-Cell Leukemia (CBCL)
Dr. Nicole Lamanna
Oncology | Hematology

Trustees Of Columbia University In The City Of New York

622 W 168th St, 
New York, NY 
212-305-9876
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Nicole Lamanna is an Oncologist and a Hematologist in New York, New York. Dr. Lamanna is rated as an Elite provider by MediFind in the treatment of Chronic B-Cell Leukemia (CBCL). Her top areas of expertise are Chronic B-Cell Leukemia (CBCL), Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL), Bone Marrow Aspiration, and Gastrostomy.

View All Doctors
What are the latest Chronic B-Cell Leukemia (CBCL) Clinical Trials?
Randomized, Phase III Study of Early Intervention With Venetoclax and Obinutuzumab Versus Delayed Therapy With Venetoclax and Obinutuzumab in Newly Diagnosed Asymptomatic High-Risk Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): EVOLVE CLL/SLL Study
Randomized, Phase III Study of Early Intervention With Venetoclax and Obinutuzumab Versus Delayed Therapy With Venetoclax and Obinutuzumab in Newly Diagnosed Asymptomatic High-Risk Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): EVOLVE CLL/SLL Study
Who is this study for: Adult patients with Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Enrollment Status: Recruiting
Publish Date: October 15, 2025
Intervention Type: Procedure, Biological, Drug, Other
Study Drugs: Obinutuzumab, Venetoclax
Study Phase: Phase 3

Summary: This phase III trial compares early treatment with venetoclax and obinutuzumab versus delayed treatment with venetoclax and obinutuzumab in patients with newly diagnosed high-risk chronic lymphocytic leukemia or small lymphocytic lymphoma. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed ...

Match to trials
Find the right clinical trials for you in under a minute
Get started
MC198B, Phase II Study of a Combination Therapy of Acalabrutinib, Venetoclax and Durvalumab in Patients With Richter Transformation From Chronic Lymphocytic Leukemia (CLL)
MC198B, Phase II Study of a Combination Therapy of Acalabrutinib, Venetoclax and Durvalumab in Patients With Richter Transformation From Chronic Lymphocytic Leukemia (CLL)
Enrollment Status: Recruiting
Publish Date: October 14, 2025
Intervention Type: Procedure, Biological, Drug
Study Phase: Phase 2

Summary: This phase II trial tests whether acalabrutinib, venetoclax, and durvalumab work in treating patients with Richter transformation from chronic lymphocytic leukemia or small lymphocytic lymphoma. Richter transformation is a rare condition in which chronic lymphocytic leukemia or small lymphocytic lymphoma changes into a fast-growing type of lymphoma. Acalabrutinib may stop the growth of cancer cell...

View All Clinical Trials