Chronic B-Cell Leukemia (CBCL)
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Learn About Chronic B-Cell Leukemia (CBCL)

View Main Condition: Leukemia

What is the definition of Chronic B-Cell Leukemia (CBCL)?
Chronic B cell leukemia is a type of chronic lymphocytic leukemia (CLL), or cancer of the blood and bone marrow that mainly affects adults. In chronic B cell leukemia, the bone marrow produces too many B lymphocytes, which are white blood cells that fight infection. Chronic B cell leukemia represents 95% of all chronic lymphocytic leukemias.
What are the symptoms of Chronic B-Cell Leukemia (CBCL)?
Individuals with early chronic B cell leukemia may not have any symptoms. Symptoms of intermediate and advanced stage chronic B cell leukemia may include painless, enlarged lymph nodes; fatigue; fever; pain in the upper left region of the abdomen; enlarged spleen; easy bruising or bleeding; pinpoint, dark red spots under the skin (petechiae); night sweats; weight loss; and frequent infections.
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What are the current treatments for Chronic B-Cell Leukemia (CBCL)?
Treatment for chronic B cell leukemia depends on the stage. Early stage chronic B cell leukemia may not need treatment and may involve watchful waiting. Treatment for intermediate and advanced stages chronic B cell leukemia may include targeted therapy, chemotherapy, radiation therapy, immunotherapy, and bone marrow or peripheral stem cell transplant.
Who are the top Chronic B-Cell Leukemia (CBCL) Local Doctors?
Kanti R. Rai
Elite in Chronic B-Cell Leukemia (CBCL)
Hematology Oncology | Hematology | Oncology
Elite in Chronic B-Cell Leukemia (CBCL)
Hematology Oncology | Hematology | Oncology

Northwell Health Center For Advanced Medicine, RJ Zuckerberg Cancer Center

450 Lakeville Road, Entrance B, 
Lake Success, NY 
Languages Spoken:
English

The Chronic Lymphocytic Leukemia (CLL) Research and Treatment Program has become a landmark for CLL patients worldwide. Dr. Kanti Rai has been involved in diagnosing and treating CLL for almost 40 years and the staging system that bears his name came out of his early breakthrough research. His particular areas of interest are: natural history of CLL, improving prognostic features of this disease and developing newer strategies of therapy which are hypothesis-driven. Dr. Rai is an active member of the International Workshop on CLL (iwCLL) and Dr. Keating s Global CLL Foundation. He is an active member of the American Society of Clinical Oncology (ASCO), American Association for Cancer Research (AACR) and the American Society of Hematology (ASH). In 2006, Dr. Rai served as the President of ASH. He was the recipient of ASCO s David Karnofsky Memorial Award in 2012. In 2013, Dr. Rai was honored with the iwCLL David Galton award. In 2014 he was presented with ASH s Wallace H. Coulter Lifetime Achievement Award. Dr. Rai is the Joel Finkelstein Cancer Foundation Professor of Medicine, and Professor of Molecular Medicine at the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell School of Medicine and Professor of Medicine at the Feinstein Institute for Medical Research, Manhasset, NY. Dr. Rai is rated as an Elite provider by MediFind in the treatment of Chronic B-Cell Leukemia (CBCL). His top areas of expertise are Chronic B-Cell Leukemia (CBCL), Chronic Lymphocytic Leukemia (CLL), Leukemia, and Richter Syndrome.

Stephen J. Schuster
Elite in Chronic B-Cell Leukemia (CBCL)
Elite in Chronic B-Cell Leukemia (CBCL)

Abramson Cancer Center Perelman 4th Floor West

3400 Civic Center Boulevard, West Pavilion, 4th Floor, 
Philadelphia, PA 
Languages Spoken:
English
Offers Telehealth

Stephen Schuster is a Hematologist in Philadelphia, Pennsylvania. Dr. Schuster is rated as an Elite provider by MediFind in the treatment of Chronic B-Cell Leukemia (CBCL). His top areas of expertise are Non-Hodgkin Lymphoma, B-Cell Lymphoma, Follicular Lymphoma, Bone Marrow Transplant, and Bone Marrow Aspiration.

 
 
 
 
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Jonathan E. Kolitz
Elite in Chronic B-Cell Leukemia (CBCL)
Hematology Oncology | Hematology | Oncology
Elite in Chronic B-Cell Leukemia (CBCL)
Hematology Oncology | Hematology | Oncology

Northwell Health Center For Advanced Medicine, RJ Zuckerberg Cancer Center

450 Lakeville Road, Entrance B, 
Lake Success, NY 
Languages Spoken:
English, Spanish
Offers Telehealth

Jonathan Kolitz, MD, FACP, is Professor of Medicine at the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell. An expert in malignant hematology, he is the System Head for Malignant Hematology for the Northwell Health Cancer Institute where he guides the clinical care and research activities of faculty and fellows. Board certified in Internal Medicine, Hematology and Medical Oncology, Dr. Kolitz has been a member of the Leukemia Core Committee of the CALGB/Alliance since 1993. He has focused on the development, conduct and publication of innovative clinical trials for the treatment of hematologic malignancies, especially acute leukemia. He has been principal investigator for numerous novel drug trials and has been involved in multiple national and international collaborations, leading to over 200 publications. As an attending physician at the Monter Cancer Center, Dr. Kolitz focuses on providing compassionate, personalized, evidence-based care. Dr. Kolitz earned his medical degree from the Yale University School of Medicine. He trained in Internal Medicine at North Shore University Hospital and Hematology and Medical Oncology at Memorial Sloan-Kettering Cancer Center. Dr. Kolitz is an active member of the American Society of Hematology, American Society of Clinical Oncology and the American College of Physicians. Dr. Kolitz is rated as an Elite provider by MediFind in the treatment of Chronic B-Cell Leukemia (CBCL). His top areas of expertise are Leukemia, Chronic B-Cell Leukemia (CBCL), Acute Myeloid Leukemia (AML), Chronic Lymphocytic Leukemia (CLL), and Bone Marrow Aspiration.

What are the latest Chronic B-Cell Leukemia (CBCL) Clinical Trials?
An Open-Label, Phase 1/2 Study of JCAR017 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma (017004)

Summary: This is a Phase 1/2, open-label, multicenter study to determine the efficacy and safety of JCAR017 in adult subjects with relapsed or refractory CLL or SLL. The study will include a Phase 1 part to determine the recommended dose of JCAR017 monotherapy in subjects with relapsed or refractory CLL or SLL, followed by a Phase 2 part to further assess the efficacy and safety of JCAR017 monotherapy trea...

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A Phase 3, Open-label, Randomized Study to Compare the Efficacy and Safety of Nemtabrutinib (MK-1026) Plus Venetoclax Versus Venetoclax Plus Rituximab in Participants With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Following at Least 1 Prior Therapy (BELLWAVE-010)

Summary: The purpose of this study is to assess the safety and tolerability and to confirm the dose of nemtabrutinib in combination with venetoclax in participants with R/R CLL/SLL. The primary study hypotheses are that the combination of nemtabrutinib plus venetoclax is superior to VR with respect to progression-free survival (PFS) per 2018 International Workshop on Chronic Lymphocytic Leukemia (iwCLL) cr...