Pain Reprocessing Therapy in Post-Operative Knee Pain

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Behavioral, Other
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

The goal of this clinical trial is to learn whether Pain Reprocessing Therapy (PRT) can help adults with knee pain after knee replacement surgery. The study is comparing PRT to usual care (the regular treatment people get after surgery) to see which works better for relieving pain. The main questions the study aims to answer are: 1. Does PRT help lower pain in people who have chronic knee pain after knee surgery? 2. How do the effects of PRT compare with usual care in terms of pain relief and other factors such as anxiety, depression, and sleep? 3. How does PRT impact the brain? Participants will: 1. Be randomly assigned to receive either PRT or usual care. 2. Complete questionnaires about their pain and health. 3. If in the PRT group, have eight weekly therapy sessions over video calls with a therapist. 4. If interested, may also take part in an optional EEG test to measure brain activity related to pain.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients are deemed eligible at 3 months post-operatively if: The patient completed a primary knee replacement \[surgery completed without complication and patient exhibits full mechanical joint function, as determined by the treating physician (good range of motion, stability, and wound healing; absence of swelling)\] and patient reports last week average knee pain ≥ 4 of 10 on Numeric Rating Scale (NRS).

• Reported pre-operative chronic knee pain of at least 6 months duration prior to surgery

• The procedure was a primary (not a revision) knee replacement

• Proficient in English

Locations
United States
Colorado
University of Colorado Anschutz Medical Campus
ACTIVE_NOT_RECRUITING
Aurora
New York
Hospital for Special Surgery
RECRUITING
New York
Contact Information
Primary
Allina Nocon, PhD
Complexjoint@hss.edu
212-774-2572
Time Frame
Start Date: 2025-06-01
Estimated Completion Date: 2026-09-30
Participants
Target number of participants: 110
Treatments
Experimental: Pain reprocessing therapy (PRT)
PRT has five components: 1) education about the origin of pain in the brain, its reversibility, and the pain-fear cycle; 2) reinforcing education using personal biography; 3) somatic tracking of pain through mindfulness and reappraisal of pain sensations as non-dangerous; 4) lowering the level of personal threat that may trigger pain sensation; and 5) inducing positive affect in periods of pain. Patients will attend eight 50-minute, therapist-led sessions. Pacing will be weekly, for approximately eight weeks.Treatment will be provided by experienced PRT clinicians. All PRT sessions will be remotely delivered.
Other: Usual Care
Participants will be asked to continue whatever they are already doing to care for their knee pain. Length of the usual care condition will be eight weeks, the expected completion time of the PRT arm.
Related Therapeutic Areas
Sponsors
Collaborators: Weill Medical College of Cornell University, Hospital for Special Surgery, New York
Leads: University of Colorado, Denver

This content was sourced from clinicaltrials.gov