Chronic T-Cell Leukemia (CTCL)
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Chronic T-Cell Leukemia (CTCL) Overview

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Learn About Chronic T-Cell Leukemia (CTCL)

View Main Condition: Leukemia

What is the definition of Chronic T-Cell Leukemia (CTCL)?
Chronic T-cell leukemia is a type of chronic lymphocytic leukemia (CLL), or cancer of the blood and bone marrow that mainly affects adults. In chronic T-cell leukemia, there is an overproduction of T lymphocytes, which are white blood cells that fight infection. Chronic T-cell leukemia has four subtypes: 1) large granular lymphocytic leukemia (LGLL), which is slow-growing; 2) T-cell prolymphocytic leukemia (T-PLL), which is aggressive, or fast-growing; 3) adult T-cell leukemia/lymphoma (ATLL); and 4) Sezary syndrome, which is a type of T-cell lymphoma that only occurs on the skin.
What are the symptoms of Chronic T-Cell Leukemia (CTCL)?
Individuals with early chronic T-cell leukemia may not have any symptoms. Symptoms of intermediate and advanced stage chronic T-cell leukemia depend on the type and may include painless, enlarged lymph nodes; fatigue; fever; pain in the upper left region of the abdomen; enlarged spleen; easy bruising or bleeding; pinpoint, dark red spots under the skin (petechiae); rash; frequent urination and/or constipation; night sweats; weight loss; abdominal pain or fullness; and frequent infections.
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What are the current treatments for Chronic T-Cell Leukemia (CTCL)?
Treatment for chronic T-cell leukemia depends on the type and stage. Early stage chronic T-cell leukemia may not need treatment and may involve watchful waiting. Treatments for intermediate and advanced stages chronic T-cell leukemia may include targeted therapy, chemotherapy, radiation therapy, immunotherapy, splenectomy, and bone marrow or peripheral stem cell transplant.
Who are the top Chronic T-Cell Leukemia (CTCL) Local Doctors?
Elite in Chronic T-Cell Leukemia (CTCL)
Elite in Chronic T-Cell Leukemia (CTCL)
Referral may be required

UT MD Anderson Cancer Center

210 Ashville Ave # 408, 
Cary, NC 
713-792-6161
Languages Spoken:
English
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Tapan Kadia is a Hematologist practicing medicine in Cary, North Carolina. Dr. Kadia is rated as an Elite provider by MediFind in the treatment of Chronic T-Cell Leukemia (CTCL). He is also highly rated in 39 other conditions, according to our data. His clinical expertise encompasses Acute Myeloid Leukemia (AML), Leukemia, Myelodysplastic Syndrome (MDS), Bone Marrow Aspiration, and Bone Marrow Transplant.

Elite in Chronic T-Cell Leukemia (CTCL)
Elite in Chronic T-Cell Leukemia (CTCL)
Referral may be required
Joseph Stelzmann Str. 26, 
Koeln, NW, DE 

Michael Hallek practices practicing medicine in Koeln, Germany. Mr. Hallek is rated as an Elite expert by MediFind in the treatment of Chronic T-Cell Leukemia (CTCL). He is also highly rated in 21 other conditions, according to our data. His clinical expertise encompasses Chronic Lymphocytic Leukemia (CLL), Chronic B-Cell Leukemia (CBCL), Leukemia, Bone Marrow Transplant, and Bone Graft.

 
 
 
 
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Elite in Chronic T-Cell Leukemia (CTCL)
Elite in Chronic T-Cell Leukemia (CTCL)
Referral may be required
Albert Einstein Allee 23, 
Ulm, BW, DE 

Stephan Stilgenbauer practices practicing medicine in Ulm, Germany. Mr. Stilgenbauer is rated as an Elite expert by MediFind in the treatment of Chronic T-Cell Leukemia (CTCL). He is also highly rated in 18 other conditions, according to our data. His clinical expertise encompasses Chronic B-Cell Leukemia (CBCL), Chronic Lymphocytic Leukemia (CLL), Leukemia, Bone Marrow Transplant, and Bone Graft.

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What are the latest Chronic T-Cell Leukemia (CTCL) Clinical Trials?
Phase Ib/II Trial of Cladribine/Ruxolitinib/Venetoclax in Patients With Relapsed/Refractory T-cell Prolymphocytic Leukemia
Phase Ib/II Trial of Cladribine/Ruxolitinib/Venetoclax in Patients With Relapsed/Refractory T-cell Prolymphocytic Leukemia
Enrollment Status: Recruiting
Publish Date: August 12, 2026
Intervention Type: Drug
Study Phase: Phase 1/Phase 2

Summary: The goal of this clinical research study is to learn if the combination of ruxolitinib with cladribine and venetoclax can help to control the disease in patients with R/R T-PLL.

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The T-cell Lymphoma Master Repository (TCLMR): A Prospective Databank of Patients With T-cell Lymphoma With Clinical Annotation and Matched Tumor Specimens
The T-cell Lymphoma Master Repository (TCLMR): A Prospective Databank of Patients With T-cell Lymphoma With Clinical Annotation and Matched Tumor Specimens
Enrollment Status: Recruiting
Publish Date: May 20, 2026
Intervention Type: Other

Summary: The purpose of this registry study is to create a database-a collection of information-for better understanding T-cell lymphoma. Researchers will use the information from this database to learn more about how to improve outcomes for people with T-cell lymphoma.

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