Added Value, Performance and Acceptance of the GFAP-UCH-L1 Pair in the Evaluation of Subjects with Mild Traumatic Brain Injury (MTBI) At Intermediate Risk of Complications
The goal of this observational study is to evaluate the performance of UCH-L1 and GFAP combined in patients with a mild traumatic brain injury. The main question : • Does the combination of UCH-L1 and GFAP can exclude brain injuries detected with CT scan in the first twelve hours after a mild traumatic brain injury? Participants will do the exams planed in routine care and : * during the expected blood sampling an additional blood sample will be done, * seven days after the discharge a call will be done by the investigator.
• Traumatic brain injury defined by
‣ Impact on the skull or the face AND OR
⁃ Acceleration / deceleration
• Glasgow Coma Scal 13, 14 or 15
• One of the following 4 criteria:
‣ \> 65 years treated with anti-platelet agent,
⁃ GCS \< 15 two hours after the trauma if associated intoxication (alcohol, narcotic, psychotropic),
⁃ Trauma with high kinetics (for information only: a risk mechanism (pedestrian knocked down by a motorized vehicle, ejection from a vehicle, fall from more than 3 steps (more than one meter), etc.),
⁃ Amnesia of facts \> 30 min before the trauma.
• Having a blood sample taken as part of care with a delay between the clinical event and the biological sample \< 12 hours
• Having a CT-scan prescription as part of the MTBI evaluation
• Patient who signed an informed consent form