Biomarkers of Fetal Infection and Disease Following Maternal HCMV Infection
Status: Unknown
Location: See location...
Intervention Type: Biological
Study Type: Observational
SUMMARY
The purposes of this study are to determine 1) if the diagnosis of CMV fetal infection could be done directly in the maternal blood instead of requesting an amniocentesis and 2) if innovative technologies such as proteomic, transcriptomic, methylomic and lipidomic applied in fetal samples could allow the discovery of new biomarkers of fetal infection.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: f
View:
⁃ CMV cases:
• Informed consent obtained from the mother;
• Pregnant women either with a history of primary CMV infection in pregnancy or carrying a fetus with ultrasound features compatible with CMV infection and willing to have amniocentesis for fetal diagnosis of CMV infection
⁃ Control cases :
⁃ \- Pregnant women carrying a fetus with aneuploidy-dysgonosomy
Locations
Other Locations
France
Hôpital Necker Enfants-Malades
RECRUITING
Paris
Contact Information
Primary
Marianne LERUEZ, MD, PhD
marianne.leruez@aphp.fr
+33 (0) 1 44 49 49 49 62
Backup
Hélène MOREL
helene.morel@aphp.fr
+33 1 71 19 63 46
Time Frame
Start Date: 2016-12
Completion Date: 2023-06
Participants
Target number of participants: 265
Treatments
CMV cases
bio-specimen collected for pregnant women with CMV infection
Control cases
bio-specimen collected for pregnant women carrying a fetus with aneuploidy-dysgonosomy
Related Therapeutic Areas
Sponsors
Leads: Assistance Publique - Hôpitaux de Paris