Learn About Congenital Diaphragmatic Hernia
Congenital diaphragmatic hernia is a defect in the diaphragm. The diaphragm, which is composed of muscle and other fibrous tissue, separates the organs in the abdomen from those in the chest. Abnormal development of the diaphragm before birth leads to defects ranging from a thinned area in the diaphragm to its complete absence. An absent or partially formed diaphragm results in an abnormal opening (hernia) that allows the stomach and intestines to move into the chest cavity and crowd the heart and lungs. This crowding can lead to underdevelopment of the lungs (pulmonary hypoplasia), potentially resulting in life-threatening breathing difficulties that are apparent from birth.
Congenital diaphragmatic hernia has many different causes. In 10 to 15 percent of affected individuals, the condition appears as a feature of a disorder that affects many body systems, called a syndrome. Donnai-Barrow syndrome, Fryns syndrome, and Pallister-Killian mosaic syndrome are among several syndromes in which congenital diaphragmatic hernia may occur. Some of these syndromes are caused by changes in single genes, and others are caused by chromosomal abnormalities that affect several genes.
Congenital diaphragmatic hernia affects approximately 1 in 2,500 newborns.
Isolated congenital diaphragmatic hernia is rarely inherited. In almost all cases, there is only one affected individual in a family.
Erasmus MC
Dick Tibboel practices in Rotterdam, Netherlands. Mr. Tibboel is rated as an Elite expert by MediFind in the treatment of Congenital Diaphragmatic Hernia. His top areas of expertise are Congenital Diaphragmatic Hernia, Diaphragmatic Hernia, Esophageal Atresia, Fasciotomy, and Endoscopy.
Anne Greenough practices in London, United Kingdom. Ms. Greenough is rated as an Elite expert by MediFind in the treatment of Congenital Diaphragmatic Hernia. Her top areas of expertise are Bronchopulmonary Dysplasia, Premature Infant, Congenital Diaphragmatic Hernia, Diaphragmatic Hernia, and Endoscopy.
Cleveland Clinic Children's Outpatient Center
Darrell Cass is a Pediatric Surgeon and a Pediatrics provider in Cleveland, Ohio. Dr. Cass is rated as an Elite provider by MediFind in the treatment of Congenital Diaphragmatic Hernia. His top areas of expertise are Congenital Diaphragmatic Hernia, Diaphragmatic Hernia, Hernia, Endoscopy, and Ureteral Reconstruction.
Summary: The purpose of the study is to determine the infant survival and long-term effects of performing Fetoscopic Endoluminal Tracheal Occlusion (FETO) surgery and removal of the BALT Goldbal2 balloon at Children's Mercy Hospital. We hypothesize that FETO balloon placement may increase survival and decrease morbidity when compared to standard prenatal care for the treatment of severe left or right conge...
Summary: The SuNDiAL study will measure levels of two naturally occurring amino acids: Arginine and Asymmetric Dimethylarginine (ADMA) in neonates undergoing abdominal surgery in the first 5 days of life due to congenital abdominal malformations as the participants recover from surgery. The investigators hypothesise that the relationship between Arginine and ADMA may be useful in predicting recovery and co...
Published Date: December 01, 2019
Published By: National Institutes of Health