A Feasibility Study on the Use of Plant Based Omega-3-Fatty Acids (Flaxseed) to Improve Inflammation Driven Pain Outcomes in Children With Sickle Cell Anemia
Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Sickle cell disease (SCD) is associated with significant morbidity and mortality. Pain and many adverse outcomes occurring in sickle cell disease are inflammatory driven. Recent data has shown that gut dysbiosis is present in individuals with sickle cell disease. Gut dysbiosis has been linked to inflammation in certain diseases. Omega -3-fatty acids (fish oil) has been shown to improve pain outcomes in individuals with sickle cell disease, but its acceptance is variable. The aim of this study is to determine if a plant-based omega-3-fatty acids will be more acceptable and also improve outcomes in individuals with sickle cell disease
Eligibility
Participation Requirements
Sex: All
Minimum Age: 5
Maximum Age: 18
Healthy Volunteers: f
View:
• Diagnosis of sickle cell anemia HbSS or HbSB0 thal at steady state
• Age 5-18 years old
Locations
United States
Alabama
University of Alabama at Birmingham
RECRUITING
Birmingham
Contact Information
Primary
Dike
cdike@uabmc.edu
2056389918
Time Frame
Start Date: 2023-08-30
Estimated Completion Date: 2026-12-30
Participants
Target number of participants: 30
Treatments
No_intervention: Regular diet
Participants will continue their regular diet.
Experimental: Plant based omega 3 Fatty Acid
Participants ingest their regular diet supplemented with a plant-based omega-3-FA
Related Therapeutic Areas
Sponsors
Leads: University of Alabama at Birmingham
Collaborators: National Heart, Lung, and Blood Institute (NHLBI)