Transcranial Direct Current Stimulation (tDCS) With Verb Network Strengthening Treatment (VNeST) in Chronic Aphasia

Status: Recruiting
Location: See location...
Intervention Type: Behavioral, Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The purpose of this study is to assess changes in language abilities of participants with chronic, post-stroke aphasia following an 8-week therapy period combined with brain stimulation. The investigators use a stimulation method called transcranial direct current stimulation (tDCS). The investigators cover two electrodes in damp sponges, place them on the scalp, and pass a weak electrical current between them. Some of this current passes through the brain and can change brain activity. One electrode is placed over language areas a bit above and in front of the left ear. The other is placed on the forehead above the right eye. Stimulation is provided twice a week for 8 weeks during aphasia therapy. The investigators believe that this stimulation may increase the effectiveness of therapy.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 21
Maximum Age: 80
Healthy Volunteers: t
View:

• Right handed (pre-stroke for participants with aphasia)

• High school education or equivalent

• Native English fluency without early 2nd language exposure (before age 10)

• Ability to perform the required discourse and MRI tasks (determined via in-person screening)

⁃ Additional INCLUSION Criteria for participants with APHASIA:

• Single-event left hemisphere stroke \> 6 months prior to enrollment

• Aphasia diagnosis per Western Aphasia Battery-Revised

• Not receiving any other speech therapy for the entire study period (20 weeks)

• Ability to perform the required therapy tasks (determined via in-person screening)

Locations
United States
New York
City University of New York
RECRUITING
New York
Contact Information
Primary
E. Susan Duncan, PhD, CCC-SLP
esduncan@gc.cuny.edu
212 817 8804
Time Frame
Start Date: 2025-01-03
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 30
Treatments
Experimental: A-tDCS & speech-language therapy
Anodal transcranial direct current stimulation (2 milliamps \[mA\]) plus aphasia therapy for 16 sessions (20-minutes per each 60-minute treatment session) over the course of 8 weeks. The electrical current will be administered over ventral inferior frontal gyrus. The stimulation will be delivered at an intensity of 2 milliamps (mA) for a maximum of 20 minutes.
Sham_comparator: Sham-tDCS & speech-language therapy
Sham transcranial direct current stimulation (2 milliamps \[mA\]) plus aphasia therapy for 16 sessions (20-minutes per each 60-minute treatment session) over the course of 8 weeks. Electrodes will be placed as in A-tDCS. Current will be ramped up for the first 30 seconds following which the intensity will drop to 0 milliamps (mA).
Related Therapeutic Areas
Sponsors
Leads: City University of New York

This content was sourced from clinicaltrials.gov