Neuromodulation for Rehabilitation of Post-Stroke Fatigue: An rTMS Pilot Study

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This experimental trial is investigating the use of magnetic stimulation of the brain as a possible treatment for people with post-stroke fatigue. Fatigue is a common condition after a stroke and can negatively impact an individual's ability to perform desired social and physical activities. Magnetic stimulation of the brain has been shown to improve signs and symptoms of related psychological (e.g., depression) conditions. Participants in this trial will receive a type of magnetic stimulation called repetitive magnetic stimulation, or rTMS. The investigators will measure feelings of fatigue, and other clinical characteristics related to mood and cognition, before and after participants receive rTMS.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 35
Maximum Age: 80
Healthy Volunteers: f
View:

• 35 - 80 years of age

• more than 6 months post-stroke

• able to walk 10m unassisted

• Clinically present fatigue

Locations
United States
South Carolina
Ralph H. Johnson VA Medical Center, Charleston, SC
RECRUITING
Charleston
Contact Information
Primary
Korey Little, BS
korey.little@va.gov
(843) 379-4328
Backup
Brian J Cence
brian.cence@va.gov
(843) 792-2668
Time Frame
Start Date: 2023-04-10
Estimated Completion Date: 2027-10-29
Participants
Target number of participants: 60
Treatments
Experimental: Real M1 High Frequency rTMS
Participants will be randomly assigned to receive high-frequency repetitive transcranial magnetic stimulation (rTMS) to the top of their head for approximately 40 minutes.
Experimental: Real LDLPFC High Frequency rTMS
Participants will be randomly assigned to receive high-frequency repetitive transcranial magnetic stimulation (rTMS) to the left frontal part of their head for approximately 40 minutes.
Sham_comparator: Sham rTMS
Participants will be randomly assigned to receive sham/placebo repetitive transcranial magnetic stimulation (rTMS) to the their head for approximately 40 minutes. This is a control condition.
Related Therapeutic Areas
Sponsors
Leads: VA Office of Research and Development
Collaborators: Ralph H. Johnson VA Medical Center

This content was sourced from clinicaltrials.gov