The Pivotal Study of RapidPulseTM Aspiration System as Frontline Approach for Patient With Acute Ischemic Stroke Due to Large Vessel Occlusions

Status: Recruiting
Location: See all (30) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trials is to demonstrate the safety and effectiveness for the RapidPulseTM Aspiration System in patients experiencing acute ischemic stroke within 8 hours of symptom onset or last seen normal. Subjects will undergo mechanical thrombectomy (a procedure to remove a clot in the brain which is preventing blood flow), with the RapidPulseTM Aspiration System. Participation in the trial is for 90 days.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:

• Age 18 to 80 years

• Clinical diagnosis of acute ischemic stroke with NIH Stroke Scale (NIHSS) score ≥ 6

• Able to be treated within 8 hours of symptom onset or last known normal (LKN)

• Able to be treated within 120 minutes from the time of the qualifying baseline CT/MR image

• Pre-morbid Modified Rankin Scale (mRS) score 0-1

• Angiographic confirmation of large vessel occlusion (LVO) in the anterior (intracranial ICA or MCA M1 or M2 segments) or posterior circulation (vertebral or basilar arteries) as confirmed by digital subtraction angiography (DSA) irrespective of IV thrombolysis administration

• Candidate to receive treatment with ADAPT technique (Direct Aspiration First-Pass Technique)

Locations
United States
California
Providence Saint John's Medical Foundation
NOT_YET_RECRUITING
Torrance
Connecticut
Yale University
NOT_YET_RECRUITING
New Haven
Florida
Baptist Health Research Institute
NOT_YET_RECRUITING
Jacksonville
University of South Florida
NOT_YET_RECRUITING
Tampa
Georgia
Emory University at Grady
NOT_YET_RECRUITING
Atlanta
Iowa
State University of Iowa
NOT_YET_RECRUITING
Iowa City
Illinois
Rush University Medical Center
NOT_YET_RECRUITING
Chicago
Advocate Aurora Research Institute
NOT_YET_RECRUITING
Park Ridge
Indiana
Indiana University Health
NOT_YET_RECRUITING
Indianapolis
Missouri
Washington University
NOT_YET_RECRUITING
St Louis
New Jersey
Cooper Health System
NOT_YET_RECRUITING
Camden
New York
State University of New York at Buffalo
NOT_YET_RECRUITING
Buffalo
Icahn School of Medicine at Mount Sinai
NOT_YET_RECRUITING
New York
Pennsylvania
UPMC
NOT_YET_RECRUITING
Pittsburgh
South Carolina
Prisma Health
NOT_YET_RECRUITING
Greenville
Tennessee
Semmes Murphey Foundation - Baptist Memorial Hospital
NOT_YET_RECRUITING
Memphis
Vanderbilt University Medical Center
NOT_YET_RECRUITING
Nashville
Texas
Valley Baptist Medical Center - Harlingen
NOT_YET_RECRUITING
Harlingen
Other Locations
France
Centre Hospitalier Universitaire de Bordeaux
NOT_YET_RECRUITING
Bordeaux
Centre Hospitalier Universitaire de Montpellier
NOT_YET_RECRUITING
Montpellier
Centre Hospitalier Universitaire de Toulouse
NOT_YET_RECRUITING
Toulouse
Spain
Hospital General Universitario Dr. Balmis
NOT_YET_RECRUITING
Alicante
Hospital Universitari Germans Trias i Pujol
RECRUITING
Badalona
Hospital Universitari de Bellvitge
RECRUITING
Barcelona
Hospital Universitari Vall d' Hebron
RECRUITING
Barcelona
Hospital Universitari de Girona Dr. Josep Trueta
NOT_YET_RECRUITING
Girona
Hospital Universitario 12 de Octubre
NOT_YET_RECRUITING
Madrid
Hospital Universitario de la Princesa
NOT_YET_RECRUITING
Madrid
Hospital Universitario La Paz
NOT_YET_RECRUITING
Madrid
Turkey
Istanbul Aydan Universitesi VM Medical Park Florya Hastanesi
NOT_YET_RECRUITING
Istanbul
Contact Information
Primary
Cynthia Yang
cyang@rapidpulsemed.com
9498367402
Time Frame
Start Date: 2025-03-27
Estimated Completion Date: 2026-12
Participants
Target number of participants: 170
Treatments
Experimental: Treatment Arm
Each subject will undergo baseline evaluation for acute ischemic stroke due to large vessel occlusion, per standard of care and undergo mechanical thrombectomy procedure, aspiration to remove the thrombus in the neuro-vasculature using the RapidPulseTM Aspiration System.
Related Therapeutic Areas
Sponsors
Leads: RapidPulse, Inc

This content was sourced from clinicaltrials.gov