• Age: 18-75 years old

• Acute ischemic stroke

• Time from onset to randomization ≤48h; if onset time is unknown, time from last known well to randomization ≤48h

• Meet the following BAD Diagnostic Imaging Criteria

⁃ 1. DWI infarcts: single (isolated) deep (subcortical) infarcts;

⁃ 2. The culprit arteries are either Lenticulostriate artery (LSA) or Paramedian pontine artery (PPA), and the infarct lesion on DWI conforms to one of the following characteristics (A/B): A. LSA: 1) Comma-like infarct lesions with Fan-shaped extension from bottom to top in the coronary position; or 2) ≥ 3 layers (layer thickness 5-7 mm) on axial DWI brain images; B. PPA: The infarct lesion extends from the deep pons to the ventral pons on the axial DWI brain images;

⁃ 3. No more than 50% stenosis on the parent artery of the criminal artery (i.e. corresponding basilar or middle cerebral artery) (Confirmed by magnetic resonance angiography \[MRA\] or computed tomography angiography \[CTA\] or digital substraction angiography \[DSA\]).

• Singed informed consent by the patient or legally authorized representatives.