Interference During Motor Learning of Different Degrees of Freedom in the Paretic Upper Extremity of People With Stroke

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Post-stroke rehabilitation of the upper extremity is a challenge in neurorehabilitation. Selective training of different degrees of freedom (training of specific monoarticular movements and in one plane of movement of the upper extremity) to achieve true recovery could be a good approach. However, it is not known how the training should be structured to avoid interference between the different movements trained, hindering the motor learning process during neurorehabilitation. This research aims to determine the effect on performance and kinematic control of a selective movement control task during one- or three-days training of 2 different degrees of freedom, close or distant in cortical representation, of the upper extremity in people with early subacute and chronic phase of stroke. The hypothesis is that in the upper extremity of subacute or chronic phase stroke survivors, learning 1 target DoF is interfered by training another DoF of the same joint. In contrast, learning 1 DoF from a different, distant joint does not interfere with learning the target DoF in a training session. Likewise, this interference is diminished in multiple training sessions. On the other hand, in early post-stroke phase, within the first 5 weeks, the gain in kinematic control of each controlled DoF is greater than in later post-stroke phases (between 9 to 12 weeks of evolution or chronic phase). An experimental design of 4 days of training, of approximately 60 minutes per day, will be carried out in people who are within the first 3 months after a stroke or in a chronic stage. There will be 3 intervention groups that will train the shoulder flexion movement of the paretic upper extremity and another movement, which can be of the same affected upper extremity or another of the contralateral lower extremity.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 85
Healthy Volunteers: t
View:

• Stroke diagnosis

• Muscular strength according to the MRC scale of 2 or more in the shoulder flexor, shoulder abductor and wrist extensor muscles.

Locations
Other Locations
Spain
Unitat de dany Cerebral Adquirit
RECRUITING
Valencia
Universitat de Valencia
RECRUITING
Valencia
Contact Information
Primary
Trinidad Bruna-Melo, MSc
tribrume@uv.alumni.es
+34657278264
Backup
María Luz Sánchez-Sánchez, Ph.D
+34672423273
Time Frame
Start Date: 2024-01-22
Estimated Completion Date: 2025-07-31
Participants
Target number of participants: 99
Treatments
Experimental: Control Group
This group will train the DoF target (shoulder flexo-extension) and DoF dorsi-ankle flexion of the contralateral lower extremity.
Experimental: Proximal Interference Group
This group will train the DoF target and shoulder abduction-adduction DoF.
Experimental: Distal Interference Group
This group will train the DoF Tf and the wrist flexion-extension DoF.
Related Therapeutic Areas
Sponsors
Leads: University of Valencia

This content was sourced from clinicaltrials.gov