Efficacy of High-dosage, High-intensity Rehabilitation Program on the Motor Recovery After Stroke in Subacute Patients

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Background: Stroke is the leading cause of long-term disability, and the second leading cause of death in the western world. Most stroke survivors will suffer from motor and cognitive disturbances for the rest of their life, which negatively affects their normal daily life. Despite the decline in stroke-related mortality over the past decades, the outcome of rehabilitation programs does not improve, and is predictable regardless of the program used. Still, several human and animal studies show that high capacity of training in the early stages post stroke improve motor recovery. This notion is far from being well established. Aim: Studying the effect of high-dosage, high-intensity training program in the subacute period on upper extremity motor recovery. Population: Stroke survivors. Study duration: 6 months. Study protocol: Participants will receive additional technology-based upper extremity training for 120 min/day, 5d/w, 4 weeks. They will be monitored pre and post training, and 6 months post-stroke. Outcome measures will include clinical, kinematic and adherence measures (see complete list in the protocol).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age ≥18 years

• Ischemic or hemorrhagic stroke (hemispheric or brainstem) confirmed by CT or MRI

• First-ever stroke or previous stroke with no upper extremity weakness

• 1 week ≤ Time after stroke onset ≤ 6 weeks

• Active shoulder flexion of at least 20◦ and partial wrist and/or finger active movement

• Ability to provide inform consent

Locations
Other Locations
Israel
Adi Negev-Nahalat Eran
NOT_YET_RECRUITING
Ofakim
Adi Negev-Nahalat Eran
RECRUITING
Ofakim
Contact Information
Primary
Gil Meir
gilmeir10@gmail.com
+972 0548340307
Time Frame
Start Date: 2025-07-13
Estimated Completion Date: 2027-07-15
Participants
Target number of participants: 50
Treatments
Experimental: This group will be provided with additional rehab time during the sub actue phase.
Participants will receive additional technology-based upper extremity training for 120 min/day, 5d/w, 4 weeks.~The program will be tailored to their impairment level, and will be added to the usual treatment given during hospitalization.
No_intervention: Matched group from an ongoing project with identical criteria.
This group is comprised of patients with similar characteristics and the intervention group will be compared to this group.
Sponsors
Collaborators: Ben-Gurion University of the Negev
Leads: Adi Negev-Nahalat Eran

This content was sourced from clinicaltrials.gov