Role of Vascular Endothelial Function After Spinal Cord Injury Related Cardiovascular Disease Risk

Status: Recruiting
Location: See location...
Intervention Type: Drug, Procedure
Study Type: Observational
SUMMARY

Individuals with spinal cord injury have heart attacks and strokes more frequently, and much earlier in life. People with spinal cord injuries develop plaque in vessels much faster, and the reasons why are unclear. Doctors generally attributed the increased risk with weight gain and developing diabetes, but many studies have shown that even without these common factors, plaque in vessels is developing more often and faster. Endothelial cells are a single layer of cells that line all vessels in the body and plays an important role in vessel health. Damage to endothelial cells is known to lead to heart attacks and strokes. Past studies on endothelial cells of people with spinal cord injury have been unclear. The investigators have new data that these cells are unhealthy after spinal cord injury a measurement. This includes measuring endothelial health by directly altering its function using a catheter in the arm and measuring small particles in blood called endothelial microvesicles. If the project is successful, the investigators will learn important information on the health of endothelial cells after spinal cord injury. The investigators will also be able to use these markers of endothelial cell function to create treatments to improve vessel health and prevent heart attacks and strokes later in life in people with spinal cord injury.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 89
Healthy Volunteers: t
View:

• Men and women of all races, ethnic backgrounds\>18 years of age

• Traumatic spinal cord injury (Sports, Assault, Transport, Fall, Other Traumatic Causes)

• Time since injury (\> 12 months)

• Paraplegia Motor Complete Injury (neurological level of injury at T2 or below, ASIA Impairment Scale A or B

Locations
United States
Colorado
Craig Hospital
RECRUITING
Englewood
Contact Information
Primary
Clare Morey, SLP-CCC
cmorey@craighospital.org
303-789-8621
Backup
Andrew Park, MD
apark@craighospital.org
303-789-8101
Time Frame
Start Date: 2024-09-01
Estimated Completion Date: 2027-03-30
Participants
Target number of participants: 60
Treatments
Spinal Cord Injury
Men and women of all races, ethnic backgrounds, over the age of 18 years: adults with chronic (\>12 months), motor complete (AIS A/B) SCI with paraplegia (neurological level of injury \[NLI\] at T2 or below).
Control (Non-Spinal Cord Injury)
Non-injured men and women of all races, ethnic backgrounds, over the age of 18 years.
Related Therapeutic Areas
Sponsors
Leads: Craig Hospital
Collaborators: University of Colorado, Boulder

This content was sourced from clinicaltrials.gov

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