Endothelial Dysfunction After SCI: Mechanism and Therapeutic Target for SCI-related Cardiovascular Disease
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY
This study plans to learn how endothelial cells, single cell lining of blood vessels may be dysfunctional after a spinal cord injury. Endothelial dysfunction will be measured by the capacity of blood vessels to vasodilate (increase in size) and alter blood flow is lower in adults with a spinal cord injury in comparison to adults without a spinal cord injury. The mechanisms which may alter this function may be critical in reducing the risk of heart attacks and strokes in people with spinal cord injuries.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:
• Over age 18 years
• Chronic (\>12 months) SCI
• Motor complete (AIS A/B) SCI
• Paraplegia (neurological level of injury \[NLI\] at T2 or below)
⁃ • Over age 18 years
Locations
United States
Colorado
Craig Hospital
RECRUITING
Englewood
Contact Information
Primary
Genevieve Madera, BS
Gmadera@craighospital.org
17203454640
Backup
Clare Morey, SLP-CCC
Gquintero@craighospital.org
303.789. 8621
Time Frame
Start Date: 2025-07-31
Estimated Completion Date: 2027-07-30
Participants
Target number of participants: 40
Treatments
Spinal Cord Injury
Willing and eligible adults over the age of 18 years who sustained a motor complete (AIS A/B) paraplegia (neurological level of injury at T2 or below) spinal cord injury greater than 12 months ago. Participants of all races and ethnic backgrounds will be included in this study.
Control (Non-Spinal Cord Injury)
Adults greater than 18 years of age who have never sustained a spinal cord injury. Participants of all races and ethnic backgrounds will be included in this study
Related Therapeutic Areas
Sponsors
Leads: Craig Hospital
Collaborators: University of Colorado, Boulder, Denver Health and Hospital Authority