Powering Up Stroke Rehabilitation Through High-Intensity Interval Training

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Objectives: To investigate the effects of high-intensity interval training (HIIT) on musculoskeletal fitness in chronic stroke survivors. Hypothesis to be tested: HIIT, performed on a recumbent stepper, will significantly enhance muscle power in chronic stroke survivors when compared with moderate-intensity continuous training (MICT) Design and subjects: Assessor-blinded, stratified, randomised, placebo-controlled clinical trial involving eligible 66 chronic stroke survivors. Interventions: Participants will be randomly allocated to one of three groups: the HIIT group, the MICT group, or a stretching group (active control). Each group will attend sessions three times per week for 12 consecutive weeks, totaling 36 training sessions. Main outcome measures: Assessments will be conducted at baseline, at mid-term of the intervention (week 6), at the end of the intervention (week 12), and at a 12-week follow-up (week 24). The primary outcome measure will be muscle power. Secondary outcome measures will include muscle strength, body composition, biomarkers, motor function, balance function, cardiorespiratory response, and psychosocial response.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Maximum Age: 80
Healthy Volunteers: f
View:

• Men and postmenopausal women aged 50-80 years

• 1-5 years following the first-ever stroke confirmed by magnetic resonance imaging or computed tomography

• Able to walk 10 meters independently with or without a walking aid

• Class I or II according to the New York Heart Association Functional Classification (no limitation or slight limitation of physical activity due to symptoms during ordinary physical activity)

Locations
Other Locations
Hong Kong Special Administrative Region
The Hong Kong Polytechnic University
RECRUITING
Kowloon
Contact Information
Primary
Chen Xu, PhD student
rschen.xu@connect.polyu.hk
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Backup
Meizhen Huang, PhD
mei-zhen.huang@polyu.edu.hk
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Time Frame
Start Date: 2024-08-20
Estimated Completion Date: 2026-04-30
Participants
Target number of participants: 66
Treatments
Experimental: High-intensity interval training
The HIIT session will consist of a 3-minute warm-up, a 20-minute main exercise, and a 2-minute cool-down. The main exercise for HIIT will include ten high-intensity intervals, interspersed with ten low-intensity intervals.
Active_comparator: Moderate-intensity continuous training
The MICT session will consist of a 3-minute warm-up, a main exercise that is isoenergetic with the HIIT session (lasting approximately 30 minutes), and a 2-minute cool-down. The intensity during the main exercise for MICT will remain constant throughout the session.
Active_comparator: Stretching
The stretching group will receive 25 minutes of whole-body stretching.
Related Therapeutic Areas
Sponsors
Leads: The Hong Kong Polytechnic University

This content was sourced from clinicaltrials.gov