Thrombolysis in Early Acute Ischemic Stroke Trial-Blood Pressure Management, EAST-BP
This study is a Phase II, exploratory, prospective, multicenter, open-label, randomized controlled clinical trial with blinded endpoint assessment setting on the safety of an adjusted versus a conventional blood pressure management strategy during intravenous thrombolysis in AIS patients, with a key focus on the incidence of symptomatic intracranial hemorrhage (sICH).
• Age 18 to 80 years (inclusive);
• Patients with acute ischemic stroke;
• Planned to receive intravenous thrombolysis within 4.5 hours of onset;
• Elevated blood pressure: Before receiving intravenous thrombolysis treatment, blood pressure is elevated: systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 100 mmHg (defined as two consecutive measurements within 2 minutes);
• Informed consent signed (or signed by a proxy).