High-intensity Exercise in Stroke Recovery: Randomized Trial

Status: Recruiting
Location: See all (4) locations...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to evaluate the effects of a high-intensity exercise program on recovery in individuals with post-stroke aphasia. The high-intensity exercise program has been specifically designed for individuals with post-stroke aphasia and includes an interval training full-body workout, which can increase cardiovascular fitness, improve muscle strength and motor performance, and maximize cognitive and language gains. The main question this study aims to answer is: • Does participation in a high-intensity exercise program lead to changes in physical health, language, cognitive, motor recovery, psychological and/or psychosocial domains? Participants will be randomly assigned to either a high-intensity exercise program (target intervention) or a low-intensity exercise program (control intervention) delivered over 12-weeks in a group setting. Outcome measures will be collected once immediately after the intervention period and once during the following 12-week maintenance period to capture short- and long-term effects of the exercise program.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:

• Aphasia following ischemic or hemorrhagic stroke

• Aphasia as determined by a standardized language test (Western Aphasia Battery Aphasia Quotient \< 93.8 at study intake)

• At least 6 months from the last stroke

• Proficient in English before the stroke

• At least 8 years of education

• Between the ages of 18 and 80

• Independent with ambulation without a device (single-point cane accepted)

• Medically stable with no contraindications to participate in regular physical exercise as determined by the patients' own primary care provider or other treating provider.

Locations
United States
California
University of California, Berkeley
RECRUITING
Berkeley
California State University, East Bay
RECRUITING
Hayward
University of California, San Francisco
RECRUITING
San Francisco
University of San Francisco
RECRUITING
San Francisco
Contact Information
Primary
Maria Ivanova, PhD
ivanova@berkeley.edu
650-390-7572
Time Frame
Start Date: 2025-12
Estimated Completion Date: 2030-10-31
Participants
Target number of participants: 120
Treatments
Experimental: High-intensity physical exercise
The participants will take part in a high-intensity Aphasia Physical EXercise (APEX) intervention designed specifically for individuals with chronic post-stroke aphasia for 12 weeks.
Active_comparator: Low-intensity physical exercise
The participants will participate in a low-intensity non-aerobic exercise program for 12 weeks.
Related Therapeutic Areas
Sponsors
Collaborators: National Institute on Deafness and Other Communication Disorders (NIDCD), University of San Francisco, California State University, East Bay, University of California, San Francisco
Leads: University of California, Berkeley

This content was sourced from clinicaltrials.gov