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Changes in Hemodynamic Response Following Transcranial Electrical Stimulation in Sroke Individuals

Status: Recruiting
Location: See location...
Intervention Type: Other, Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The present study will use transcranial electrical stimulation (tES) which are transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) combined with conventional physical therapy and cognitive-motor dualt ask gait training in sub-acute (at least 2 weeks after stroke onset) to chronic stroke (within 5 years post-stroke) to investigate changes in brain hemodynamics (oxy-hemoglobin and deoxy-hemoglobin concentration) as measured by functional near infrared spectroscopy (fNIRS). The findings may provides insights changes in combining tES with rehabilitation on improvements in brain hemodynamics in sub-acute to chronic stroke.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:

• Unilateral stroke individuals aged 18-80 years.

• A first-ever stroke.

• Stroke onset from at least 2 weeks-5 years.

• Able to walk independently with or without gait aids (modified Rankin scale (mRS) 1-3)

• Montreal cognitive Assessment-Thai version (MoCA-T) greater than or equal to 20 scores.

• Ability to read, communicate, follow and understand instructions.

Locations
Other Locations
Thailand
Faculty of Physical Therapy, Mahidol University
RECRUITING
Salaya
Contact Information
Primary
Wanalee Klomjai, PhD
wanalee.klo@mahidol.edu
+6624415450
Time Frame
Start Date: 2026-03-01
Estimated Completion Date: 2027-03-30
Participants
Target number of participants: 60
Treatments
Active_comparator: transcranial direct current stimulation with rehabilitation
Participants received active tDCS for 20 minutes followed by rehabilitation program for 12 sessions (3 days/week, 4 weeks)
Active_comparator: transcranial alternating current stimulation with rehabilitation
Participants received active tACS for 20 minutes followed by rehabilitation program for 12 sessions (3 days/ week, 4 weeks)
Sham_comparator: sham stimulation with rehabilitation
Participants receive sham tDCS for 20 minutes with electrical current delivered only 1 minutes followed by rehabilitation program for 12 sessions (3 days/ week, 4 weeks)
Related Therapeutic Areas
Sponsors
Leads: Mahidol University

This content was sourced from clinicaltrials.gov