Exercise Physiology After Thrombosis (EXERT): a Prospective Single Centre Cohort Study of Cardiovascular and Exercise Physiology in Patients With Previous Venous Thrombosis in the Inferior Vena Cava and Iliofemoral Veins.
Deep vein thrombosis (DVT) can cause long-term scarring and narrowing of veins. When there is extensive damage to the veins in the legs, groin or abdomen it can affect the way that blood is able to flow back up to the heart. Some patients are left with severe symptoms such as pain, leg swelling and ulcers, and have surgical treatment with nitinol stents to re-open the veins and relieve symptoms. The primary aim of this study is to investigate venous blood flow to the heart during exercise in patients with extensive damage to the veins in the groin and abdomen after DVT, and changes that happen after stenting.
‣ All groups:
• \>16 years of age
‣ \- Consent to participate in the research study and be willing to commit to study requirements, including completion of questionnaires and follow up visits.
‣ Group 1:
⁃ Venous thrombosis/obstruction involving the inferior vena cava \>12 months ago.
⁃ Symptoms of exertional dyspnoea reported by patient.
⁃ Judged by the chief investigator as suitable for surgical intervention before recruitment to the study.
⁃ Agree to adhere to therapeutic anticoagulation after surgical intervention.
‣ Group 2:
⁃ Venous thrombosis/obstruction involving the inferior vena cava \>12 months ago.
⁃ Under the clinical care of the deep venous service for surveillance of symptoms.
‣ Group 3:
⁃ Unilateral Iliofemoral venous thrombosis /obstruction \>12 months ago.
⁃ Judged by the chief investigator as suitable for surgical intervention before recruitment to the study.
⁃ Agree to adhere to therapeutic anticoagulation after surgical intervention.