Effect of Anti Xa Monitoring Low Molecular Weight Heparin (LMWH) on Prevention of Venous Thromboembolism in Critically Ill Patients:A Randomized Controlled Trial

Status: Unknown
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism, is a common cardiovascular disease associated with significant morbidity ranging from painful leg swelling, chest pain, shortness of breath, and even death. About 50% of all VTE events occur as a result of a current or recent hospital admission for surgery or acute medical illness. Hospital-acquired VTE is preventable, with interventions including anticoagulants and mechanical measures, including compression stockings and intermittent pneumatic compression. Prevented hospital acquired VTE is the focus of health services and the strongest hospital strategy to improve patient health in the world.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Aged 18 years or older

• No gender limited

• Prospectively screened for risk and included if they received LMWH

• The patient or his / her legal representative is able and willing to sign the informed consent

Locations
Other Locations
China
Xuanwu Hospital, Capital Medical University
RECRUITING
Beijing
Contact Information
Primary
Chunmei Wang, MD
drwangchunmei@sina.com
+0086-13681359526
Time Frame
Start Date: 2022-05-16
Completion Date: 2024-12-31
Participants
Target number of participants: 858
Treatments
Experimental: Peak value anti-Xa group (Group A)
The peak value of anti-Xa level of this group should be remain 0.3~0.5IU/mL. This group will receive low molecular weight heparins (LMWH) 40mg, once a day for the first 3 days. And detect the peak level of anti-Xa after 4 to 6 hours after injection of the third dose of LMWH. Adjust the dose of LMWH according to the peak value of anti Xa.
Experimental: Trough value anti-Xa group (Group B)
The trough value of anti-Xa level of this group should be remain 0.1~0.2IU/mL. This group will receive low molecular weight heparins (LMWH) 40mg, once a day for the first 3 days. And detect the trough level of anti-Xa after 12 hours after injection of the third dose of LMWH. Adjust the dose of LMWH according to the trough value of anti Xa.
Placebo_comparator: Control group (Group C)
The control group will not detect the value of anti Xa and not adjust the dose of LMWH.~This group will receive fixed dose of low molecular weight heparins (LMWH) 40mg, once a day.
Sponsors
Collaborators: Peking University First Hospital
Leads: Xuanwu Hospital, Beijing

This content was sourced from clinicaltrials.gov

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