Comparison Between the Efficacy of Rivaroxaban vs Enoxaparin in Post-Operative Deep Venous Thrombosis Prophylaxis After Exploratory Laparotomy

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

The goal of this clinical trial is to learn if rivaroxaban works better than enoxaparin to prevent deep vein thrombosis (DVT) after emergency exploratory laparotomy in adults. It will also learn about the safety of rivaroxaban compared to enoxaparin. The main questions it aims to answer are: Does rivaroxaban lower the number of patients who develop DVT after exploratory laparotomy compared to enoxaparin? What medical problems or side effects do participants have when taking rivaroxaban versus enoxaparin? Researchers will compare rivaroxaban (an oral anticoagulant) to enoxaparin (a subcutaneous injection) to see which drug works better to prevent blood clots after surgery. Participants will: Take rivaroxaban 10 mg orally once daily for 7 days, or enoxaparin 40 mg subcutaneously once daily for 7 days after surgery Undergo duplex color Doppler ultrasound scans of the legs on day 5 and day 10 after surgery Be monitored for bleeding, complications, and other side effects

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:

• Both male or female patients

• Patients who have undergone emergent exploratory laparotomy for any reason whether traumatic or non-traumatic

• Patients with expected immobility for more than 24 hours

Locations
Other Locations
Pakistan
Mayo Hospital Lahore
RECRUITING
Lahore
Contact Information
Primary
Muhammad Mashhood Shad, FCPS
mashhood_shad@yahoo.com
+923040420285
Backup
Shahroze Wajid, FCPS
mashhood0285@gmail.com
+923054480616
Time Frame
Start Date: 2025-10-10
Estimated Completion Date: 2025-11-15
Participants
Target number of participants: 212
Treatments
Active_comparator: Rivaroxaban Group
Arm 1 Title: Rivaroxaban Group Arm Type: Experimental Intervention Name: Drug: Rivaroxaban Descri
Active_comparator: Enoxaparin Group
Arm 2 Title: Enoxaparin Group~Arm Type: Active Comparator~Intervention Name: Drug: Enoxaparin~Description: Participants receive enoxaparin 40 mg subcutaneously once daily for 7 days after emergency exploratory laparotomy, in addition to standard perioperative care and mechanical prophylaxis.
Sponsors
Leads: Mayo Hospital Lahore
Collaborators: King Edward Medical University

This content was sourced from clinicaltrials.gov