Trial to Reduce Antimicrobial Use In Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0 (TRAIN-AD 2.0)

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

The goal of this pragmatic cluster randomized clinical trial is to compare management of suspected infection in nursing home residents with dementia The main questions it aims to answer whether residents with dementia in nursing homes randomized to use a multicomponent intervention to optimize suspected infection management ( versus usual care) use less antibiotics and fewer burdensome interventions.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 60
Maximum Age: 106
Healthy Volunteers: f
View:

• Age \> 60

• A diagnosis of dementia (any type)

• Cognitive Functional Scale (CFS) \> 1

• NH length of stay \>90 days

⁃ The CFS score categorizes cognitive impairment status based on data in the electronic health record into: 1. None, 2. Mild, 3. Moderate, and 4. Severe (advanced). For the primary outcome, the analysis will be restricted to residents with a CFS score of 3 or 4.

Locations
United States
Massachusetts
Hebrew SeniorLife
RECRUITING
Boston
Contact Information
Primary
Susan Mitchell, MD, MPH
smitchell@hsl.harvard.edu
16172813669
Time Frame
Start Date: 2023-11-13
Estimated Completion Date: 2026-06-30
Participants
Target number of participants: 750
Treatments
Experimental: TRAIN AD 2.0
Nursing homes randomized to the experimental arm will emply a multicomponent intervention among their providers designed to improve the management of suspected infections in residents with dementia. The components include: a.Orientation sessions for providers, b.On-line case based course for providers, c.Infection management algorithms for providers, d. Guidelines for providers to communicate with proxies, and e. Education booklet about infections in dementia for providers.
Active_comparator: Usual Care
Nursing homes randomized to the conrol arm will employ usual care to manage nursing home residents with dementia with suspected infections.
Sponsors
Leads: Hebrew SeniorLife
Collaborators: Brown University

This content was sourced from clinicaltrials.gov

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