Light, Metabolic Syndrome and Alzheimer's Disease: A Non-Pharmocological Approach
Status: Completed
Location: See all (2) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
To test the long term effect of a light treatment on cognition, sleep and metabolism in patients with Mild cognitive impairment (MCI) or mild Alzheimer's disease or related dementia (ADRD).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 55
Healthy Volunteers: f
View:
• Mild cognitive impairment
• Mild Alzheimer's Disease
• Sleep Disturbance
• Live at home
Locations
United States
New Jersey
Rutgers University
New Brunswick
New York
Icahn School of Medicine at Mount Sinai
New York
Time Frame
Start Date: 2019-01-02
Completion Date: 2025-05-31
Participants
Target number of participants: 25
Treatments
Active_comparator: Active Lighting Intervention
The TLI will provide high circadian stimulation during the day produced by light sources that provide moderate light levels of spectra that are tuned to the sensitivity of the circadian system. Combining spectrum and light level, TLI will allow us to: (a) use a light source that will stimulate the circadian system, and (b) provide the participants with options as to how the light treatment will be delivered. The investigators will deliver at least 300-400 lux at the eye of the bluish-white light during the day (CS of 0.4 or greater).~The lighting intervention will be in place for 24 weeks
Placebo_comparator: Placebo Lighting Intervention
The placebo condition light source will be a warm yellow - white (2700 - 3000 K) source providing 50 -100 lux at the eye. The lighting intervention will be in place for 24 weeks.
Related Therapeutic Areas
Sponsors
Leads: Icahn School of Medicine at Mount Sinai