Phase II Clinical Trial of Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

While many have strongly suggested that transcranial direct current stimulation (tDCS) may represent a beneficial intervention for patients with primary progressive aphasia (PPA), this promising technology has not yet been applied widely in clinical settings. This treatment gap is underscored by the absence of any neurally-focused standard-of-care treatments to mitigate the devastating impact of aphasia on patients' family, work, and social lives. Given that tDCS is inexpensive, easy to use (it is potentially amenable to home use by patients and caregivers), minimally invasive, and safe there is great promise to advance this intervention toward clinical use. The principal reason that tDCS has not found wide clinical application yet is that its efficacy has not been tested in large, multi-center, clinical trials. In this study, scientists in the three sites that have conducted tDCS clinical trials in North America-Johns Hopkins University and the University of Pennsylvania in the US, and the University of Toronto in Canada, will collaborate to conduct a multi-site, Phase II clinical trial of tDCS a population in dire need of better treatments.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Maximum Age: 90
Healthy Volunteers: t
View:

• Presence of aphasia attributable to non-fluent PPA or logopenic PPA

• High school education (or more)

• Between the ages of 50 and 80

• Must be able to understand the nature of the study and give informed consent

Locations
United States
Maryland
Johns Hopkins Hospital
RECRUITING
Baltimore
Pennsylvania
University of Pennsylvania
RECRUITING
Philadelphia
Other Locations
Canada
Baycrest Centre for Geriatric Care
RECRUITING
Toronto
Contact Information
Primary
Kelly Eun, B.S.
krmeun@jhmi.edu
(410) 929 - 0279
Backup
Kyrana Tsapkini, PhD.
tsapkini@jhmi.edu
410-736-2940
Time Frame
Start Date: 2024-02-13
Estimated Completion Date: 2028-02-01
Participants
Target number of participants: 180
Treatments
Experimental: Active tDCS + Language Therapy first
Active tDCS will be applied at the beginning of 45 minutes language therapy session and will last for 20 minutes.
Sham_comparator: Sham tDCS + Language Therapy first
Sham tDCS will be applied at the beginning of 45 minutes language therapy session.
Authors
Kyrana Tsapkini
Sponsors
Collaborators: National Institute on Aging (NIA)
Leads: Johns Hopkins University

This content was sourced from clinicaltrials.gov